Faculty of Fundamental Medicine, Lomonosov Moscow State University.
Acta Naturae. 2012 Jan;4(1):23-31.
Immune cells responsible for inflammation development are involved in tissue damage caused by wounding and various pathologies. Control of immune cell activation could be of significant benefit for regenerative medicine and the treatment of patients with autoimmune and degenerative diseases. It is a proven fact that MCSs (multipotent mesenchymal stromal cells) are capable of suppressing immune responses via the inhibition of dendritic cell maturation and via the restraining of the T, B, and NK cell function in the course of autoimmune diseases and various forms of inflammation. MSCs can be isolated easily from almost every type of tissue or organ and subsequently expandedin vitro. These cells are self-renewable and can be differentiated into various cell types of mesenchymal lineage. The current review contains a collection and critical analysis of data regarding the molecular mechanisms responsible for cross-talk between immune cells and MSCs. Some of these mechanisms can be used for the development of new practical approaches for the treatment of autoimmune diseases.
负责炎症发展的免疫细胞参与了创伤和各种病理引起的组织损伤。免疫细胞激活的控制可能对再生医学和自身免疫性和退行性疾病患者的治疗有重大意义。事实证明，间充质基质细胞（MCSs）能够通过抑制树突状细胞成熟和在自身免疫性疾病和各种形式的炎症过程中抑制 T、B 和 NK 细胞的功能来抑制免疫反应。MCSs 可以很容易地从几乎每一种类型的组织或器官中分离出来，并在体外进行扩增。这些细胞具有自我更新能力，可以分化为各种间充质谱系的细胞类型。这篇综述收集并批判性分析了关于免疫细胞和 MCSs 之间相互作用的分子机制的数据。其中一些机制可用于开发治疗自身免疫性疾病的新实用方法。
