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主动脉根部扩张合并重度主动脉瓣反流的外科治疗:Bentall手术与保留瓣膜手术的比较

Surgical Management of Aortic Root Dilatation with Advanced Aortic Regurgitation: Bentall Operation versus Valve-sparing Procedure.

作者信息

Lim Ju Yong, Kim Joon Bum, Jung Sung-Ho, Choo Suk Jung, Chung Cheol Hyun, Lee Jae Won

机构信息

Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Korea.

出版信息

Korean J Thorac Cardiovasc Surg. 2012 Jun;45(3):141-7. doi: 10.5090/kjtcs.2012.45.3.141. Epub 2012 Jun 7.

Abstract

BACKGROUND

Although the aortic valve-sparing procedure has gained popularity in recent years, it still remains challenging in patients with advanced aortic regurgitation (AR). We compared the long-term outcomes of the aortic valve-sparing procedure with the Bentall operation in patients with advanced aortic regurgitation secondary to aortic root dilatation.

MATERIALS AND METHODS

A retrospective review of 120 patients who underwent surgery for aortic root dilatation with moderate to severe AR between January 1999 and June 2009 was performed. Forty-eight patients underwent valve-sparing procedures (valve-sparing group), and 72 patients underwent the Bentall procedure (Bentall group). The two groups' overall survival, valve-related complications, and aortic valve function were compared.

RESULTS

The mean follow-up duration was 4.9±3.1 years. After adjustment, the valve-sparing group had similar risks of death (hazard ratio [HR], 0.61; p=0.45), and valve related complications (HR, 1.27; p=0.66). However, a significant number of patients developed moderate to severe AR in the valve-sparing group at a mean of 4.4±2.5 years of echocardiographic follow-up (p<0.001).

CONCLUSION

Both the Bentall operation and aortic valve-sparing procedure showed comparable long-term clinical results in patients with advanced aortic regurgitation with aortic root dilatation. However, recurrent advanced aortic regurgitation was more frequently observed following valve-sparing procedures.

摘要

背景

尽管近年来保留主动脉瓣手术越来越受欢迎,但对于重度主动脉瓣反流(AR)患者而言,该手术仍具有挑战性。我们比较了保留主动脉瓣手术与Bentall手术治疗因主动脉根部扩张导致重度主动脉瓣反流患者的长期疗效。

材料与方法

对1999年1月至2009年6月期间因主动脉根部扩张合并中重度AR而接受手术的120例患者进行回顾性分析。48例患者接受了保留瓣膜手术(保留瓣膜组),72例患者接受了Bentall手术(Bentall组)。比较两组的总生存率、瓣膜相关并发症及主动脉瓣功能。

结果

平均随访时间为4.9±3.1年。调整后,保留瓣膜组的死亡风险(风险比[HR],0.61;p=0.45)和瓣膜相关并发症风险(HR,1.27;p=0.66)相似。然而,在保留瓣膜组中,经超声心动图随访平均4.4±2.5年时,有相当数量的患者出现了中重度AR(p<0.001)。

结论

对于因主动脉根部扩张导致重度主动脉瓣反流的患者,Bentall手术和保留主动脉瓣手术的长期临床结果相当。然而,保留瓣膜手术后复发性重度主动脉瓣反流更为常见。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8831/3373968/9d69dad10757/kjtcs-45-141-g001.jpg

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