Kozaki Sachiko, Takenaka Yukiko, Mizushina Yoshiyuki, Yamaura Takao, Tanahashi Takao
Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe, 658-8558, Japan.
J Nat Med. 2014 Apr;68(2):421-6. doi: 10.1007/s11418-013-0803-y. Epub 2013 Oct 16.
Phytochemical investigation of the leaves and twigs of Acronychia pedunculata has led to the isolation of three new acetophenone monomers 1-3 as well as 1-[2',4'-dihydroxy-3',5'-di-(3″-methyl-2″-butenyl)-6'-methoxy]phenylethanone (4), acronyculatin E (5), a mixture of β-sitosterol and stigmasterol, and sesamin. The structures of these new compounds were elucidated spectroscopically. The inhibitory activities of the isolated acetophenone derivatives against mammalian DNA polymerases and human cancer cell growth were also assessed.
对山油柑叶和嫩枝进行植物化学研究，已分离出三种新的苯乙酮单体1 - 3以及1 - [2',4'-二羟基-3',5'-二-(3″-甲基-2″-丁烯基)-6'-甲氧基]苯乙酮（4）、山油柑素E（5）、β-谷甾醇和豆甾醇的混合物以及芝麻素。通过光谱学方法阐明了这些新化合物的结构。还评估了分离出的苯乙酮衍生物对哺乳动物DNA聚合酶和人类癌细胞生长的抑制活性。
