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一些喀麦隆香料甲醇提取物对革兰氏阴性多药耐药表型的抗菌及抗生素增效活性

Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes.

作者信息

Voukeng Igor K, Kuete Victor, Dzoyem Jean P, Fankam Aimé G, Noumedem Jaures A K, Kuiate Jules R, Pages Jean-Marie

机构信息

Department of Biochemistry, Faculty of science, University of Dschang, P,O, Box 67, Dschang, Cameroon, Africa.

出版信息

BMC Res Notes. 2012 Jun 15;5:299. doi: 10.1186/1756-0500-5-299.

DOI:10.1186/1756-0500-5-299
PMID:22709668
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3438083/
Abstract

BACKGROUND

The present work was designed to evaluate the antibacterial properties of the methanol extracts of eleven selected Cameroonian spices on multi-drug resistant bacteria (MDR), and their ability to potentiate the effect of some common antibiotics used in therapy.

RESULTS

The extract of Cinnamomum zeylanicum against Escherichia coli ATCC 8739 and AG100 strains showed the best activities, with the lowest minimal inhibitory concentration (MIC) of 64 μg/ml. The extract of Dorstenia psilurus was the most active when tested in the presence of an efflux pump inhibitor, phenylalanine Arginine-β- Naphtylamide (PAβN), a synergistic effect being observed in 56.25 % of the tested bacteria when it was combined with erythromycin (ERY).

CONCLUSION

The present work evidently provides information on the role of some Cameroonian spices in the fight against multi-resistant bacteria.

摘要

背景

本研究旨在评估11种喀麦隆香料的甲醇提取物对多重耐药菌（MDR）的抗菌特性，以及它们增强一些常用治疗抗生素效果的能力。

结果

锡兰肉桂提取物对大肠杆菌ATCC 8739和AG100菌株表现出最佳活性，最低抑菌浓度（MIC）为64μg/ml。在存在外排泵抑制剂苯丙氨酸精氨酸-β-萘酰胺（PAβN）的情况下进行测试时，扁序麻提取物活性最强，当它与红霉素（ERY）联合使用时，在56.25%的测试细菌中观察到协同效应。

结论

本研究明显提供了一些喀麦隆香料在对抗多重耐药菌方面作用的信息。

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