Institut Pasteur, Unité de mycologie moléculaire, Paris, France.
Antimicrob Agents Chemother. 2012 Sep;56(9):4948-50. doi: 10.1128/AAC.05990-11. Epub 2012 Jun 18.
The relationship between the azole preexposure of 86 patients and the genotype, azole susceptibility, and cyp51A polymorphisms of 110 corresponding Aspergillus fumigatus isolates was explored. Isolates carrying serial polymorphisms (F46Y and M172V with or without N248T with or without D255E with or without E427K) had higher itraconazole MICs (P = 0.04), although <2 μg/ml using the EUCAST methodology, were associated with two genetic clusters (P < 0.001) and with voriconazole preexposure of patients (P = 0.016). Voriconazole preexposure influences the distribution of A. fumigatus isolates with selection of isolates carrying cyp51A polymorphisms and higher itraconazole MICs.
探讨了 86 例患者的唑类药物预暴露与 110 株相应烟曲霉分离株的基因型、唑类药物敏感性、cyp51A 多态性之间的关系。携带连续多态性（F46Y 和 M172V 以及 N248T 或 D255E 或 E427K）的分离株伊曲康唑 MIC 较高（P = 0.04），尽管采用 EUCAST 方法学<2 μg/ml，但与两个遗传群集（P<0.001）和患者伏立康唑预暴露（P = 0.016）相关。伏立康唑预暴露影响携带 cyp51A 多态性和较高伊曲康唑 MIC 的烟曲霉分离株的分布。
