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烟曲霉基因点突变导致慢性肺部曲霉病患者出现棘白菌素类耐药。

Emergence of Echinocandin Resistance Due to a Point Mutation in the Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis.

机构信息

Public Health Research Institute-New Jersey Medical School-Rutgers Biomedical Health Sciences, Newark, New Jersey, USA

Mycology Reference Centre, Manchester, University Hospital of South Manchester, Manchester, United Kingdom.

出版信息

Antimicrob Agents Chemother. 2017 Nov 22;61(12). doi: 10.1128/AAC.01277-17. Print 2017 Dec.

DOI:10.1128/AAC.01277-17
PMID:28923871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5700295/
Abstract

We have identified the first case of an hot spot 1 point mutation causing echinocandin resistance in a clinical isolate recovered from a chronic pulmonary aspergillosis patient with an aspergilloma who first failed azole and polyene therapy and subsequently failed micafungin treatment.

摘要

我们已经鉴定出首例临床分离株中的 1 个热点 1 点突变导致棘白菌素类耐药，该株来源于患有曲霉球的慢性肺部侵袭性曲霉病患者，该患者最初唑类和多烯类药物治疗失败，随后米卡芬净治疗也失败。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/651c/5700295/04ad48b77904/zac0121766970002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/651c/5700295/4c4f3f215d91/zac0121766970001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/651c/5700295/04ad48b77904/zac0121766970002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/651c/5700295/4c4f3f215d91/zac0121766970001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/651c/5700295/04ad48b77904/zac0121766970002.jpg

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