Pulmonology Department, University Children's Hospital, University Medical Centre, Ljubljana, Slovenia.
Respir Care. 2012 Nov;57(11):1937-44. doi: 10.4187/respcare.01771. Epub 2012 Jun 15.
A correlation has been observed between obstructive sleep events and sleep quality. The aim of the study was to assess if there is also a correlation between nocturnal hypoxemia and hypercapnia and sleep efficiency and sleep fragmentation in children.
Nocturnal pulse oximetry (S(pO(2))) and transcutaneous carbon dioxide (P(tcCO(2))) recordings with simultaneous actigraphy were performed in 38 children with nocturnal hypoxemia and hypercapnia during spontaneous breathing (nocturnal hypoventilation [NH] group), 25 children with partially corrected nocturnal hypoventilation (PC-NH group), and 11 subjects with normal nocturnal gas exchange (no-NH group).
Sleep efficiency and sleep fragmentation on actigraphy correlated with minimal S(pO(2)) (r(2) = 0.21, P = .004, and r(2) = -0.10, P = .050, respectively) and the percentage of night time with S(pO(2)) < 90% (r(2) = -0.33, P < .001, and r(2) = 0.13, P = .028, respectively) in the NH group. Sleep efficiency and sleep fragmentation also correlated with pulse rate standard deviation (r(2) = -0.42, P < .001, and r(2) = 0.37, P < .001, respectively). No correlation was observed between sleep efficiency and sleep fragmentation and P(tcCO(2)). No correlation was observed between sleep efficiency and sleep fragmentation and S(pO(2)), P(tcCO(2)), and pulse rate in the PC-NH group. Sleep efficiency, sleep fragmentation, and nocturnal S(pO(2)), and P(tcCO(2)) were all normal and not correlated in the no-NH group.
In children with nocturnal hypoventilation, nocturnal hypoxemia but not hypercapnia correlates with sleep efficiency and sleep fragmentation on actigraphy.
阻塞性睡眠事件与睡眠质量之间存在相关性。本研究旨在评估夜间低氧血症和高碳酸血症与儿童睡眠效率和睡眠片段化之间是否也存在相关性。
对 38 例夜间低氧血症和高碳酸血症伴自主呼吸的儿童（夜间低通气[NH]组）、25 例部分纠正夜间低通气的儿童（PC-NH 组）和 11 例夜间气体交换正常的儿童（无 NH 组）进行夜间脉搏血氧饱和度（S（pO（2）））和经皮二氧化碳（P（tcCO（2）））记录，并同步进行活动记录。
NH 组的活动记录仪上的睡眠效率和睡眠片段化与最小 S（pO（2））相关（r（2）= 0.21，P =.004，r（2）= -0.10，P =.050），以及夜间 S（pO（2））<90%的时间百分比（r（2）= -0.33，P <.001，r（2）= 0.13，P =.028）。睡眠效率和睡眠片段化也与脉搏率标准差相关（r（2）= -0.42，P <.001，r（2）= 0.37，P <.001）。在 NH 组中，睡眠效率和睡眠片段化与 P（tcCO（2））之间无相关性。在 PC-NH 组中，睡眠效率和睡眠片段化与 S（pO（2））、P（tcCO（2））和脉搏率之间也无相关性。在无 NH 组中，睡眠效率、睡眠片段化、夜间 S（pO（2））和 P（tcCO（2））均正常，且无相关性。
在夜间低通气的儿童中，夜间低氧血症而非高碳酸血症与活动记录仪上的睡眠效率和睡眠片段化相关。
