Institute for Glycomics, Griffith University, G26/4.30 Gold Coast Campus, Gold Coast, QLD, 4222, Australia,
Curr Infect Dis Rep. 2012 Aug;14(4):381-90. doi: 10.1007/s11908-012-0263-7.
Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are major health problems in many developing countries and Indigenous populations of developed countries. ARF and RHD are sequelae resulting from an infection of Streptococcus pyogenes. Despite advances in health care practices and technology, these diseases still pose major challenges in the communities where Streptococcus pyogenes is often endemic. Here we review and discuss the dynamic epidemiology of streptococcal infection and its associated diseases (ARF and RHD), with a focus on disease burden in temperate versus tropical regions, the tissue tropism of the organism and the efforts towards vaccine development in relation to the available animal models.
急性风湿热（ARF）和风湿性心脏病（RHD）是许多发展中国家和发达国家土著居民的主要健康问题。ARF 和 RHD 是由化脓性链球菌感染引起的后遗症。尽管医疗保健实践和技术取得了进步，但这些疾病在链球菌常流行的社区仍然构成重大挑战。在这里，我们回顾和讨论链球菌感染及其相关疾病（ARF 和 RHD）的动态流行病学，重点讨论温带与热带地区的疾病负担、病原体的组织嗜性以及与现有动物模型相关的疫苗开发工作。
