利用淋巴细胞染色体畸变分析评估水烟吸烟者的 DNA 损伤。
Assessment of DNA damage using chromosomal aberrations assay in lymphocytes of waterpipe smokers.
机构信息
Department of Applied Biological Sciences, Faculty of Science and Arts, Jordan University of Science and Technology, Irbid, Jordan.
出版信息
Int J Occup Med Environ Health. 2012 Jun;25(3):218-24. doi: 10.2478/S13382-012-0027-5. Epub 2012 Jun 22.
Abstract
OBJECTIVES
The aim of this study was to investigate the genotoxicity of waterpipe smoking in the lymphocytes of waterpipe smokers using chromosomal aberrations (CAs) assay.
MATERIALS AND METHODS
Fifty waterpipe smokers and 18 healthy non-smokers volunteered to participate in the study. Additionally, 18 heavy cigarette smokers were recruited for comparison. Chromosomal aberrations (CAs) assay was used to evaluate DNA damage in the lymphocytes.
RESULTS
The results showed that similarly to cigarette smoking, waterpipe smoking significantly increased the frequencies of CAs (p < 0.01). In addition, the frequencies of CAs increased with more waterpipe use.
CONCLUSIONS
Waterpipe smoking causes DNA damage to lymphocytes and the damage increases with more waterpipe use.
摘要
目的
本研究旨在通过染色体畸变（CA）检测，调查水烟吸烟对水烟吸烟者淋巴细胞的遗传毒性。
材料与方法
50 名水烟吸烟者和 18 名健康不吸烟者自愿参加了这项研究。此外，还招募了 18 名重度吸烟的吸烟者进行比较。染色体畸变（CA）检测用于评估淋巴细胞中的 DNA 损伤。
结果
结果表明，与吸烟类似，水烟吸烟显著增加了 CA 的频率（p<0.01）。此外，CA 的频率随水烟使用量的增加而增加。
结论
水烟吸烟导致淋巴细胞的 DNA 损伤，且损伤随水烟使用量的增加而增加。
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