Institute of Immunology and Infection Research, Centre for Immunity, Infection and Evolution, School of Biological Sciences, Ashworth Laboratories, King's Buildings, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK.
Sci Rep. 2012;2:472. doi: 10.1038/srep00472. Epub 2012 Jun 26.
Characterisation of protective helminth acquired immunity in humans or experimental models has focused on effector responses with little work conducted on memory responses. Here we show for the first time, that human helminth infection is associated with altered proportions of the CD4+ memory T cells, with an associated alteration of T(H)1 responses. The reduced CD4+ memory T cell proportions are associated with a significantly lower ratio of schistosome-specific IgE/IgG4 (marker for resistance to infection/re-infection) in uninfected older people. Helminth infection does not affect the CD8+ memory T cell pool. Furthermore, we show for the first time in a helminth infection that the CD4+ memory T cell proportions decline following curative anti-helminthic treatment despite increased CD4+ memory cell replication. Reduced accumulation of the CD4+ memory T cells in schistosome-infected people has implications for the development of natural or vaccine induced schistosome-specific protective immunity as well as for unrelated pathogens.
在人类或实验模型中，对保护性寄生虫获得性免疫的特征在于效应器反应，而对记忆反应的研究很少。在这里，我们首次表明，人类寄生虫感染与 CD4+记忆 T 细胞比例的改变有关，同时 T(H)1 反应也发生了改变。CD4+记忆 T 细胞比例的降低与未感染的老年人中血吸虫特异性 IgE/IgG4（感染/再感染抗性的标志物）的比例显著降低有关。寄生虫感染不会影响 CD8+记忆 T 细胞库。此外，我们首次在寄生虫感染中表明，尽管 CD4+记忆细胞复制增加，但在进行驱虫治疗后，CD4+记忆 T 细胞的比例仍然会下降。在感染血吸虫的人群中，CD4+记忆 T 细胞的积累减少，这对自然或疫苗诱导的血吸虫特异性保护性免疫以及与无关病原体的免疫都有影响。
