阿托品与遮盖治疗中度弱视的随机试验。
A Randomized Trial of Atropine vs Patching for Treatment of Moderate Amblyopia.
作者信息
Medghalchi A R, Dalili S
机构信息
Department of Ophthalmology, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
出版信息
Iran Red Crescent Med J. 2011 Aug;13(8):578-81. Epub 2011 Aug 1.
BACKGROUND
amblyopia is a major cause of visual impairment in children. Our aim is to compare patching and atropine penalization for treatment of moderate amblyopia in 4-10 years old children.
METHODS
During 2004-2007, in a randomized clinical trial, 120 patients aged 4-10 years old with moderate amblyopia in the range of 20/40 -20/100 were enrolled. Subjects randomized either to patch therapy or twice weekly atropine penalization in equal groups and were followed for 2 years. The success rate was defined as increment of 2 or more lines of visual acuity or final visual acuity of 20/25 or better.
RESULTS
The visual acuity in amblyopic eye improved from base line to a mean of 3.8 lines in patching group and mean of 3.7 lines in atropine group at the end of follow up. The average visual acuity in both groups was 0.5 Log MAR acuity that increased to 0.18 in patching group and 0.2 in atropine group.
CONCLUSION
Twice weekly atropine penalization could improve visual acuity of a magnitude like to improvement provided by patching in treatment of moderate amblyopia in patients aged 4-10 years.
背景
弱视是儿童视力损害的主要原因。我们的目的是比较遮盖疗法和阿托品压抑疗法对4至10岁儿童中度弱视的治疗效果。
方法
在2004年至2007年期间，一项随机临床试验纳入了120例年龄在4至10岁、弱视程度为20/40 - 20/100的中度弱视患者。受试者被随机分为两组，分别接受遮盖疗法或每周两次的阿托品压抑疗法，并随访2年。成功率定义为视力提高2行或更多行，或最终视力达到20/25或更好。
结果
随访结束时，弱视眼的视力在遮盖组从基线平均提高了3.8行，在阿托品组平均提高了3.7行。两组的平均视力均为0.5 Log MAR视力，遮盖组提高到0.18，阿托品组提高到0.2。
结论
对于4至10岁中度弱视患者，每周两次的阿托品压抑疗法提高视力的幅度与遮盖疗法相当。
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