Department of Internal Medicine, Inje University College of Medicine, Goyang, Korea.
Diabetes Metab J. 2012 Jun;36(3):237-44. doi: 10.4093/dmj.2012.36.3.237. Epub 2012 Jun 14.
Several studies in Western populations have indicated that metabolic syndrome (MetS) is inferior to the Framingham risk score (FRS) in predicting coronary heart disease (CHD). However there has been no study about the predictability of MetS vs. FRS for CHD in Korea.
Among the 43,145 persons from the third Korea National Health and Nutrition Examination Survey in 2005, laboratory test and nutritional survey data from 5,271 persons were examined. Participants were also asked to recall a physician's diagnosis of CHD.
The median age was 46 (range, 20 to 78) in men (n=2,257) and 44 (range, 20 to 78) years in women (n=3,014). Prevalence of self-reported CHD was 1.7% in men and 2.1% in women. Receiver operating characteristic curves and their respective area under the curve (AUC) were used to compare the ability of the FRS and the number of components of MetS to predict self-reported CHD in each sex. In men, AUC of FRS was significantly larger than that of MetS (0.767 [0.708 to 0.819] vs. 0.677 [0.541 to 0.713], P<0.01). In women, AUC of FRS was comparable to that of MetS (0.777 [0.728 to 0.826] vs. 0.733 [0.673 to 0.795]), and was not significant.
The data suggested that FRS was more closely associated with CHD compared to MetS in Korean men.
几项针对西方人群的研究表明，代谢综合征（MetS）在预测冠心病（CHD）方面不如弗雷明汉风险评分（FRS）。然而，在韩国，还没有关于 MetS 与 FRS 对 CHD 的预测能力的研究。
在 2005 年第三次韩国国家健康和营养检查调查中，对来自 43145 人的实验室检测和营养调查数据进行了检查，共有 5271 人参与。研究人员还要求参与者回忆医生对 CHD 的诊断。
男性（n=2257）的中位年龄为 46（范围 20 至 78）岁，女性（n=3014）为 44（范围 20 至 78）岁。男性自我报告的 CHD 患病率为 1.7%，女性为 2.1%。在每个性别中，比较 FRS 和 MetS 成分数量预测自我报告 CHD 的能力时，使用了受试者工作特征曲线及其各自的曲线下面积（AUC）。在男性中，FRS 的 AUC 显著大于 MetS（0.767[0.708 至 0.819]比 0.677[0.541 至 0.713]，P<0.01）。在女性中，FRS 的 AUC 与 MetS 相当（0.777[0.728 至 0.826]比 0.733[0.673 至 0.795]），且无统计学意义。
与女性相比，在韩国男性中，FRS 与 CHD 的相关性更密切。
