Yu Kiwoong, Kim Cheolhwan, Sung Eunju, Shin Hocheol, Lee Hyewon
Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Korean J Fam Med. 2011 Sep;32(6):327-33. doi: 10.4082/kjfm.2011.32.6.327. Epub 2011 Sep 28.
It has been suggested that bilirubin has an inverse association with cardiovascular disease (CVD) due to its antioxidant properties. However, there are few data regarding the relationship between serum total bilirubin (sTB) and risk factors for CVD in Koreans. This study aimed to evaluate the relationship between sTB and high sensitivity C-reactive protein (hsCRP), which is an independent risk factor for CVD.
We performed a cross sectional study in 6,800 men who were examined at a health promotion center at a university hospital in Korea between May 2005 and June 2006. We grouped the subjects according to values of serum hsCRP (above or below 1.0 mg/L) and compared the characteristics of the two groups. To evaluate the relationship between sTB and hsCRP, we classified the subjects according to quartile values of sTB. Multivariate logistic regression analyses were used to analyze the relationship of levels of sTB and hsCRP after adjusting for known risk factors for CVD.
Serum hsCRP was significantly associated with body mass index (BMI), smoking, diabetes, hypertension, fasting plasma glucose, systolic blood pressure, alanine aminotransferase, and total cholesterol/high density lipoprotein (TC/HDL-C) ratio, but not with age or alcohol use. As levels of sTB increased, there was a decrease in age, numbers of smokers, BMI, and TC/HDL ratio. Compared to the lowest quartile of sTB, levels of hsCRP decreased with odds ratios of 0.82 (95% CI, 0.71 to 0.96), 0.75 (95% CI, 0.65 to 0.88), and 0.63 (95% CI, 0.54 to 0.74) in the 2nd, 3rd, and 4th quartiles of bilirubin, respectively.
Bilirubin may be inversely associated with hsCRP.
由于胆红素具有抗氧化特性，有人提出胆红素与心血管疾病（CVD）呈负相关。然而，关于韩国人血清总胆红素（sTB）与CVD危险因素之间关系的数据较少。本研究旨在评估sTB与CVD独立危险因素高敏C反应蛋白（hsCRP）之间的关系。
我们对2005年5月至2006年6月期间在韩国一所大学医院健康促进中心接受检查的6800名男性进行了横断面研究。我们根据血清hsCRP值（高于或低于1.0mg/L）对受试者进行分组，并比较两组的特征。为了评估sTB与hsCRP之间的关系，我们根据sTB的四分位数对受试者进行分类。多因素逻辑回归分析用于分析在调整已知CVD危险因素后sTB和hsCRP水平之间的关系。
血清hsCRP与体重指数（BMI）、吸烟、糖尿病、高血压、空腹血糖、收缩压、丙氨酸转氨酶以及总胆固醇/高密度脂蛋白（TC/HDL-C）比值显著相关，但与年龄或饮酒无关。随着sTB水平升高，年龄、吸烟者数量、BMI和TC/HDL比值降低。与sTB最低四分位数相比，胆红素第2、3和4四分位数的hsCRP水平分别以0.82（95%CI，0.71至0.96）、0.75（95%CI，0.65至0.88）和0.63（95%CI，0.54至0.74）的优势比下降。
胆红素可能与hsCRP呈负相关。
