纵向队列研究在表观遗传流行病学中的作用：挑战与机遇。
The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities.
作者信息
Ng Jane W Y, Barrett Laura M, Wong Andrew, Kuh Diana, Smith George Davey, Relton Caroline L
出版信息
Genome Biol. 2012 Jun 29;13(6):246. doi: 10.1186/gb-2012-13-6-246.
Abstract
Longitudinal cohort studies are ideal for investigating how epigenetic patterns change over time and relate to changing exposure patterns and the development of disease. We highlight the challenges and opportunities in this approach.
摘要
纵向队列研究非常适合用于调查表观遗传模式如何随时间变化，以及与不断变化的暴露模式和疾病发展之间的关系。我们着重介绍了这种方法所面临的挑战和机遇。
相似文献
1
The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities.纵向队列研究在表观遗传流行病学中的作用：挑战与机遇。
Genome Biol. 2012 Jun 29;13(6):246. doi: 10.1186/gb-2012-13-6-246.
2
Epigenetic biomarkers in cancer epidemiology.癌症流行病学中的表观遗传生物标志物
Methods Mol Biol. 2012;863:467-80. doi: 10.1007/978-1-61779-612-8_28.
3
Epigenetic epidemiology: is there cause for optimism?表观遗传流行病学：是否有理由感到乐观？
Epigenomics. 2015 Aug;7(5):683-5. doi: 10.2217/epi.15.48. Epub 2015 Aug 28.
4
Genetic sources of population epigenomic variation.人口表观基因组变异的遗传来源。
Nat Rev Genet. 2016 Jun;17(6):319-32. doi: 10.1038/nrg.2016.45. Epub 2016 May 9.
5
A new era for epigenetic epidemiology.表观遗传流行病学的新时代。
Epigenomics. 2019 Nov 1;11(15):1647-1649. doi: 10.2217/epi-2019-0282. Epub 2019 Nov 15.
6
Epigenetic studies of schizophrenia: progress, predicaments, and promises for the future.精神分裂症的表观遗传学研究：进展、困境和未来的前景。
Schizophr Bull. 2013 Jan;39(1):11-6. doi: 10.1093/schbul/sbs139. Epub 2012 Dec 4.
7
Epigenetic Mechanisms in Asthma.哮喘中的表观遗传机制
Ann Am Thorac Soc. 2016 Mar;13 Suppl 1(Suppl 1):S48-50. doi: 10.1513/AnnalsATS.201507-420MG.
8
Epigenomics-Guided Drug Development: Recent Advances in Solving the Cancer Treatment "jigsaw puzzle".表观基因组学指导药物研发：解决癌症治疗“拼图游戏”的最新进展。
OMICS. 2019 Feb;23(2):70-85. doi: 10.1089/omi.2018.0206.
9
Epigenetics and Epigenomics: Implications for Diabetes and Obesity.表观遗传学和表观基因组学：对糖尿病和肥胖的启示。
Diabetes. 2018 Oct;67(10):1923-1931. doi: 10.2337/db18-0537.
10
[The first stage of transmission of an epigenetic character followed by fluorescence].[表观遗传特征传递的第一阶段及随后的荧光现象]
Med Sci (Paris). 2017 Aug-Sep;33(8-9):717-719. doi: 10.1051/medsci/20173308010. Epub 2017 Sep 18.
引用本文的文献
1
Environmental Xenobiotics and Epigenetic Modifications: Implications for Human Health and Disease.环境外源性物质与表观遗传修饰：对人类健康和疾病的影响
J Xenobiot. 2025 Jul 13;15(4):118. doi: 10.3390/jox15040118.
2
Human genetics and epigenetics of alcohol use disorder.酒精使用障碍的人类遗传学和表观遗传学。
J Clin Invest. 2024 Aug 15;134(16):e172885. doi: 10.1172/JCI172885.
3
A systematic scientometric review of paternal inheritance of acquired metabolic traits.父系获得性代谢特征遗传的系统科学计量学综述。
BMC Biol. 2023 Nov 13;21(1):255. doi: 10.1186/s12915-023-01744-6.
4
Using epigenomics to understand cellular responses to environmental influences in diseases.利用表观基因组学了解疾病中细胞对环境影响的反应。
PLoS Genet. 2023 Jan 19;19(1):e1010567. doi: 10.1371/journal.pgen.1010567. eCollection 2023 Jan.
5
Social Epigenomics: Conceptualizations and Considerations for Oral Health.社会表观基因组学：口腔健康的概念和思考。
J Dent Res. 2022 Oct;101(11):1299-1306. doi: 10.1177/00220345221110196. Epub 2022 Aug 3.
6
Impact of maternal dietary counseling in the first year of life on DNA methylation in a cohort of children.母亲在孩子出生第一年进行饮食咨询对一组儿童DNA甲基化的影响。
Genet Mol Biol. 2021 Dec 3;44(4):e20200330. doi: 10.1590/1678-4685-GMB-2020-0330. eCollection 2021.
7
Ten Years of EWAS.十年的 EWAS 研究。
Adv Sci (Weinh). 2021 Oct;8(20):e2100727. doi: 10.1002/advs.202100727. Epub 2021 Aug 11.
8
Social epigenomics: are we at an impasse?社会表观基因组学：我们是否陷入僵局？
Epigenomics. 2021 Nov;13(21):1747-1759. doi: 10.2217/epi-2020-0136. Epub 2021 Mar 22.
9
Clinical epigenomics for cardiovascular disease: Diagnostics and therapies.临床表观基因组学与心血管疾病：诊断与治疗。
J Mol Cell Cardiol. 2021 May;154:97-105. doi: 10.1016/j.yjmcc.2021.01.011. Epub 2021 Feb 6.
10
Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence.儿童期表观基因组范围内的 DNA 甲基化变化和变异：从出生到青春期后期的轨迹。
Hum Mol Genet. 2021 Mar 25;30(1):119-134. doi: 10.1093/hmg/ddaa280.
本文引用的文献
1
Cohort Profile: the 'children of the 90s'--the index offspring of the Avon Longitudinal Study of Parents and Children.队列特征描述：“90 后的孩子们”——雅芳纵向父母与子女研究的索引后代。
Int J Epidemiol. 2013 Feb;42(1):111-27. doi: 10.1093/ije/dys064. Epub 2012 Apr 16.
2
Cohort Profile: the Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort.队列资料简介：雅芳纵向研究父母与子女：ALSPAC 母亲队列。
Int J Epidemiol. 2013 Feb;42(1):97-110. doi: 10.1093/ije/dys066. Epub 2012 Apr 16.
3
Children of the 90s: Coming of age.90后的孩子们：成年之际。
Nature. 2012 Apr 11;484(7393):155-8. doi: 10.1038/484155a.
4
Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B12.妊娠期间遗传和非遗传因素对婴儿整体和特定部位 DNA 甲基化的影响：叶酸基因变异体和维生素 B12 的作用。
PLoS One. 2012;7(3):e33290. doi: 10.1371/journal.pone.0033290. Epub 2012 Mar 30.
5
Prenatal arsenic exposure and DNA methylation in maternal and umbilical cord blood leukocytes.产前砷暴露与孕妇及脐带血白细胞 DNA 甲基化。
Environ Health Perspect. 2012 Jul;120(7):1061-6. doi: 10.1289/ehp.1104173. Epub 2012 Mar 30.
6
Placental 11-beta hydroxysteroid dehydrogenase methylation is associated with newborn growth and a measure of neurobehavioral outcome.胎盘 11-β羟类固醇脱氢酶甲基化与新生儿生长和神经行为结果的一项指标有关。
PLoS One. 2012;7(3):e33794. doi: 10.1371/journal.pone.0033794. Epub 2012 Mar 14.
7
DNA methylation patterns in cord blood DNA and body size in childhood.脐带血 DNA 中的 DNA 甲基化模式与儿童期的体型大小。
PLoS One. 2012;7(3):e31821. doi: 10.1371/journal.pone.0031821. Epub 2012 Mar 14.
8
Gene promoter methylation is associated with lung function in the elderly: the Normative Aging Study.基因启动子甲基化与老年人肺功能有关：正常衰老研究。
Epigenetics. 2012 Mar;7(3):261-9. doi: 10.4161/epi.7.3.19216.
9
Gestational intake of methyl donors and global LINE-1 DNA methylation in maternal and cord blood: prospective results from a folate-replete population.妊娠期间甲基供体的摄入与母血和脐血中 LINE-1 整体 DNA 甲基化：叶酸充足人群的前瞻性研究结果。
Epigenetics. 2012 Mar;7(3):253-60. doi: 10.4161/epi.7.3.19082.
10
Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease.两步法表观遗传学孟德尔随机化：一种在疾病发生途径中确立表观遗传过程因果作用的策略。
Int J Epidemiol. 2012 Feb;41(1):161-76. doi: 10.1093/ije/dyr233.
Zotero 插件