Center for Intelligent Nano-Bio Materials, Department of Chemistry and Nano Science, Department of Bioinspired Science, Ewha Womans University, Seoul, Republic of Korea.
Recent Pat Nanotechnol. 2012 Nov;6(3):200-17. doi: 10.2174/187221012803531538.
This review outlines research and patents relating to the use of inorganic nanomaterial, layered double hydroxide, as nanocontainers for drug delivery and gene reservoirs. Various intercalative synthetic routes including coprecipitation, ion exchange, reconstruction and exfoliation-reassembly have been explored to incorporate drug or gene molecules. Its unique two-dimensional structure allows layered double hydroxide to act as a nanospace for the stabilization, targeted delivery or controlled release of gene or drug molecules. Intercalative hybrid nanomaterials have uses such as pharmaceutically active ingredients, in oral- or cellular delivery systems, cosmetic ingredients, molecular coding units and etc. Toxicological studies have found layered double hydroxides to be biocompatible compared with widely used nanoparticles such as iron oxide, silica, and single-walled carbon nanotubes. Due to their versatile functionality and biocompatibility, layered double hydroxides have been widely studied and their applicability can be expanded to other nanoparticle based bio-medical applications.
本文概述了无机纳米材料——层状双氢氧化物作为药物输送和基因储存纳米容器的研究和专利。已经探索了各种插层合成途径，包括共沉淀、离子交换、重构和剥离-重组，以纳入药物或基因分子。其独特的二维结构使层状双氢氧化物能够作为基因或药物分子的稳定、靶向输送或控制释放的纳米空间。插层混合纳米材料可用于药物活性成分、口服或细胞递药系统、化妆品成分、分子编码单元等。毒理学研究发现，与广泛使用的纳米粒子（如氧化铁、二氧化硅和单壁碳纳米管）相比，层状双氢氧化物具有生物相容性。由于其多功能性和生物相容性，层状双氢氧化物已得到广泛研究，其适用性可扩展到其他基于纳米粒子的生物医学应用。
