Dvivedi Jyoti, Dvivedi Sanjay
Department of Physiology, Himalayan Institute of Medical Sciences, HIHT University, Jolly Grant, Dehradun, India.
Indian J Plast Surg. 2012 Jan;45(1):115-20. doi: 10.4103/0970-0358.96602.
To study the cleft lip and cleft palate in the poverty stricken Sub-Himalayan Garhwal region of India, being a commonly seen congenital abnormality and scarcity of studies about the demography of cleft in this region.
A prospective cohort observational case series was performed on 4657 cleft patients at a Tertiary care Hospital in Dehradun, India, over a period of 5 years.
The authors investigated the differences between age and sex with cleft status and family history of clefts, birth order, religion, socioeconomic status, parent literacy, source of information for treatment, haematological investigations showing the status of infection and coagulation in such children and satisfaction after treatment.
Seventy-two percent parents of cleft lip patients were illiterate, and only 8% were graduates, the majority of patients were from the low socioeconomic class. The siblings of 1.1% of the cleft patients had similar deformity. Anemia was seen in 83.16% cases which was commonly microcytic hypochromic type and eosinophilia was seen in 25.50% of cases. In the coagulation profile, International Nationalized Ratio was found to be raised in 52.12%. Almost 95% of the families were fully satisfied by the treatment and results.
This study will provide baseline information on the status of these less privileged cleft patients in this mountainous region for future reference to health workers.
研究印度喜马拉雅山加尔瓦尔地区贫困地带的唇腭裂情况，唇腭裂是一种常见的先天性异常，而该地区关于腭裂人口统计学的研究较少。
在印度德拉敦的一家三级护理医院，对4657例腭裂患者进行了为期5年的前瞻性队列观察病例系列研究。
作者调查了年龄、性别与腭裂状态、腭裂家族史、出生顺序、宗教、社会经济地位、父母文化程度、治疗信息来源、血液学检查结果（显示此类儿童的感染和凝血状况）以及治疗后满意度之间的差异。
唇腭裂患者的父母中72%为文盲，只有8%为大学毕业生，大多数患者来自社会经济地位较低的阶层。1.1%的腭裂患者的兄弟姐妹有类似畸形。83.16%的病例出现贫血，常见为小细胞低色素性贫血，25.50%的病例出现嗜酸性粒细胞增多。在凝血指标方面，52.12%的患者国际标准化比值升高。几乎95%的家庭对治疗和结果完全满意。
本研究将为该山区这些弱势腭裂患者的状况提供基线信息，供卫生工作者未来参考。
