Bui Eric, Nadal-Vicens Mireya, Simon Naomi M
Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114, USA.
Dialogues Clin Neurosci. 2012 Jun;14(2):149-57. doi: 10.31887/DCNS.2012.14.2/ebui.
Complicated grief (CG) is a common and often under-acknowledged cause of profound impairment experienced after the loss of a loved one. Although both clinical and basic research suggests that pharmacological agents might be of use in the treatment of CG, research on pharmacological approaches to this condition is still scarce. Three open-label trials and one randomized trial on bereavement-related depression suggest that tricyclic antidepressants may be effective, although they may be more efficacious for depressive symptoms than for grief-specific symptoms. Four open-label trials (total number of participants, 50) of selective serotonin reuptake inhibitors (SSRIs) have yielded results, providing very preliminary support that they might be effective in the treatment of CG, both as a standalone treatment and in conjunction with psychotherapeutic interventions. These more recent studies have shown an effect on both depression and grief-specific scales. Furthermore, therapeutic interventions for CG may be more effective in conjunction with SSRI administration. Given the small number of pharmacological studies to date, there is a need for randomized trials to test the potential efficacy of pharmacological agents in the treatment of CG.
复杂性悲伤（CG）是亲人离世后常见且常被忽视的导致严重功能障碍的原因。尽管临床研究和基础研究均表明药物制剂可能对CG的治疗有用，但针对这种病症的药物治疗方法的研究仍然匮乏。三项开放标签试验和一项关于丧亲相关抑郁症的随机试验表明，三环类抗抑郁药可能有效，尽管它们对抑郁症状的疗效可能比对悲伤特异性症状的疗效更好。四项选择性5-羟色胺再摄取抑制剂（SSRI）的开放标签试验（参与者总数为50）得出了结果，提供了非常初步的支持，即它们可能单独或与心理治疗干预联合有效地治疗CG。这些最新研究显示对抑郁和悲伤特异性量表均有效果。此外，CG的治疗干预与SSRI给药联合使用可能更有效。鉴于迄今为止药物研究数量较少，需要进行随机试验来测试药物制剂在治疗CG方面的潜在疗效。
