Eckhoff C, Nau H
Freie Universität Berlin, Institut für Toxikologie und Embryonalpharmakologie.
Arch Toxicol. 1990;64(6):502-3. doi: 10.1007/BF01977634.
The concentrations of retinoic acid compounds were monitored by a newly developed highly sensitive HPLC procedure in plasma of six volunteers who received 833 IU vitamin A per kg body weight per day during a 20-day period. There was a significant increase of all-trans-retinoic acid (two-fold), 13-cis-retinoic acid (7-fold) and 13-cis-4-oxoretinoic acid (5-fold) over endogenous plasma levels of these retinoids. The same compounds had previously been found after treatment with the teratogenic drug isotretinoin (Roaccutan, Accutane). Our results raise the possibility that high vitamin A intake may carry a teratogenic risk attributable to increased levels of retinoic acid compounds generated from retinol by metabolic processes.
通过一种新开发的高灵敏度高效液相色谱法，对六名志愿者血浆中视黄酸化合物的浓度进行了监测。这些志愿者在20天内每天每公斤体重摄入833国际单位的维生素A。与这些类视黄醇的内源性血浆水平相比，全反式视黄酸（增加了两倍）、13-顺式视黄酸（增加了7倍）和13-顺式-4-氧代视黄酸（增加了5倍）均有显著增加。此前在用致畸药物异维A酸（保肤灵、异维甲酸）治疗后也发现了相同的化合物。我们的研究结果表明，高维生素A摄入量可能存在致畸风险，这归因于视黄醇通过代谢过程产生的视黄酸化合物水平升高。
