在进行自我评价的过程中，自闭症患者与非自闭症患者的神经和行为反应存在差异。
Neural and behavioral responses during self-evaluative processes differ in youth with and without autism.
机构信息
Department of Psychology, 1227 University of Oregon, Eugene, OR 97403-1227, USA.
出版信息
J Autism Dev Disord. 2013 Feb;43(2):272-85. doi: 10.1007/s10803-012-1563-3.
Abstract
This fMRI study investigated neural responses while making appraisals of self and other, across the social and academic domains, in children and adolescents with and without autism spectrum disorders (ASD). Compared to neurotypical youth, those with ASD exhibited hypoactivation of ventromedial prefrontal cortex during self-appraisals. Responses in middle cingulate cortex (MCC) and anterior insula (AI) also distinguished between groups. Stronger activity in MCC and AI during self-appraisals was associated with better social functioning in the ASD group. Although self-appraisals were significantly more positive in the neurotypical group, positivity was unrelated to brain activity in these regions. Together, these results suggest that multiple brain regions support making self-appraisals in neurotypical development, and function atypically in youth with ASD.
摘要
这项 fMRI 研究调查了在自闭症谱系障碍（ASD）儿童和青少年中，以及在没有自闭症谱系障碍的儿童和青少年中，在社会和学术领域进行自我和他人评价时的神经反应。与神经典型的年轻人相比，自闭症谱系障碍患者在进行自我评价时，腹内侧前额叶皮层的活动减少。扣带前回（MCC）和前岛叶（AI）的反应也能区分不同的组别。在自我评价过程中，MCC 和 AI 的活动越强，自闭症谱系障碍患者的社交功能就越好。尽管神经典型组的自我评价明显更为积极，但这些区域的大脑活动与积极性无关。总的来说，这些结果表明，在神经典型的发展过程中，多个大脑区域支持进行自我评价，而在自闭症谱系障碍的年轻人中，这些区域的功能则存在异常。
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