Centre for Human Psychopharmacology, Swinburne University of Technology, PO Box 218-H24, Hawthorn, Victoria 3122, Australia.
Psychopharmacology (Berl). 2012 Dec;224(4):581-9. doi: 10.1007/s00213-012-2787-9. Epub 2012 Jul 5.
Cannabis and alcohol are the most popular drugs amongst recreational users and most prevalent in injured and deceased drivers. The Standardized Field Sobriety Tests (SFST) are commonly used to establish impairment due to drugs and alcohol, but limited empirical evidence exists concerning the combined effects of these drugs on SFST performance.
The sample comprised 80 individuals (31 females; 49 males). Age ranged between 21 and 35 years (M = 26.5, SD = 5). Forty participants (15 females; 25 males) took part in the low alcohol condition (BAC, <0.05 %), and 40 participants (16 females; 24 males), took part in the high alcohol condition (BAC, >0.05 %). For each part of the study, two levels of ∆9-tetrahydrocannabinol (THC) were administered (1.8 and 3 % THC) or a matching placebo cigarette (0 % THC) in combination with alcohol. Performance on the SFST was assessed 30 min post-dosing.
A number of significant differences in SFST performance were identified with 28 % of the sample failing the test (when the head movement and jerks sign was included) when low alcohol and low THC were administered together. When a higher dose of alcohol was administered with a low dose of THC, 38 % of the sample failed the test, and 35 % also failed when the high dose of alcohol was combined with a higher dose of THC.
The current results highlight the limited ability of the SFST to identify drug consumption in the absence of any evidence of driving impairment or physiological indicators.
大麻和酒精是娱乐性使用者中最受欢迎的毒品,在受伤和死亡的驾驶员中最为普遍。标准化现场清醒测试(SFST)常用于确定药物引起的损害和酒精,但关于这些药物对 SFST 表现的综合影响的经验证据有限。
该样本包括 80 人(31 名女性;49 名男性)。年龄在 21 岁至 35 岁之间(M=26.5,SD=5)。40 名参与者(15 名女性;25 名男性)参加了低酒精条件(BAC,<0.05%),40 名参与者(16 名女性;24 名男性)参加了高酒精条件(BAC,>0.05%)。对于研究的每一部分,都给予了两种水平的 ∆9-四氢大麻酚(THC)(1.8%和 3% THC)或匹配的安慰剂香烟(0% THC)与酒精一起服用。在给药后 30 分钟评估 SFST 的表现。
在低酒精和低 THC 一起给予时,SFST 表现出现了一些显著差异,有 28%的样本未能通过测试(当包括头部运动和抽搐迹象时)。当给予更高剂量的酒精和低剂量的 THC 时,38%的样本未能通过测试,当高剂量的酒精与更高剂量的 THC 结合时,35%的样本也未能通过测试。
目前的结果强调了 SFST 在缺乏任何驾驶损伤或生理指标证据的情况下识别药物消耗的能力有限。