通过使用表面增强空间偏移拉曼光谱技术对 20 毫米厚的猪组织中的双膦酸盐进行追踪。
Tracking bisphosphonates through a 20 mm thick porcine tissue by using surface-enhanced spatially offset Raman spectroscopy.
机构信息
Centre for Molecular Nanometrology, WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, UK.
出版信息
Angew Chem Int Ed Engl. 2012 Aug 20;51(34):8509-11. doi: 10.1002/anie.201203728. Epub 2012 Jul 4.
Track it down: A recognized surface-enhanced Raman scattering (SERS) nanotag signal was monitored from a thin, dispersed layer of bisphosphonate-functionalized nanotags on a bone sample, through a 20 mm thick specimen of porcine muscle tissue by surface-enhanced spatial offset Raman spectroscopy (SESORS; see picture). The result demonstrates the great potential for non-invasive in vivo bisphosphonate drug tracking.
追踪
通过表面增强空间位移拉曼光谱（SESORS；见图），从骨样本上分散的、双膦酸盐功能化纳米标签薄层中监测到一个公认的表面增强拉曼散射（SERS）纳米标签信号，该样本穿过了 20 毫米厚的猪肌肉组织。研究结果表明，非侵入性体内双膦酸盐药物追踪具有巨大潜力。
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