Bioelectronics Program, Institute of Microelectronics, Singapore Science Park II, Singapore 117685, Singapore.
Anal Chim Acta. 2012 Aug 6;737:1-21. doi: 10.1016/j.aca.2012.05.048. Epub 2012 Jun 4.
Biosensors have shown great potential for health care and environmental monitoring. The performance of biosensors depends on their components, among which the matrix material, i.e., the layer between the recognition layer of biomolecule and transducer, plays a crucial role in defining the stability, sensitivity and shelf-life of a biosensor. Recently, zinc oxide (ZnO) nanostructures and thin films have attracted much interest as materials for biosensors due to their biocompatibility, chemical stability, high isoelectric point, electrochemical activity, high electron mobility, ease of synthesis by diverse methods and high surface-to-volume ratio. ZnO nanostructures have shown the binding of biomolecules in desired orientations with improved conformation and high biological activity, resulting in enhanced sensing characteristics. Furthermore, compatibility with complementary metal oxide semiconductor technology for constructing integrated circuits makes ZnO nanostructures suitable candidate for future small integrated biosensor devices. This review highlights recent advances in various approaches towards synthesis of ZnO nanostructures and thin films and their applications in biosensor technology.
生物传感器在医疗保健和环境监测方面显示出巨大的潜力。生物传感器的性能取决于其组件，其中基质材料（即生物分子的识别层和换能器之间的层）在定义生物传感器的稳定性、灵敏度和保质期方面起着至关重要的作用。最近，氧化锌 (ZnO) 纳米结构和薄膜因其生物相容性、化学稳定性、高等电点、电化学活性、高电子迁移率、易于通过多种方法合成以及高表面积与体积比而作为生物传感器材料引起了广泛关注。ZnO 纳米结构具有在所需方向上结合生物分子的能力，改善了构象并提高了生物活性，从而增强了传感特性。此外，与互补金属氧化物半导体技术的兼容性可用于构建集成电路，这使得 ZnO 纳米结构成为未来小型集成生物传感器设备的合适候选材料。本综述重点介绍了 ZnO 纳米结构和薄膜的各种合成方法的最新进展及其在生物传感器技术中的应用。
