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甲基化使肌肉进入转录因子沉默状态。

Methylation muscles into transcription factor silencing.

作者信息

Bharathy Narendra, Taneja Reshma

机构信息

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

出版信息

Transcription. 2012 Sep-Oct;3(5):215-20. doi: 10.4161/trns.20914. Epub 2012 Sep 1.

DOI:10.4161/trns.20914
PMID:22771996
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3632615/
Abstract

The transcription factor MyoD is a master regulator of skeletal muscle differentiation. The finding that G9a, an enzyme principally involved in histone H3 lysine 9 di-methylation (H3K9me2), methylates MyoD, identifies previously unappreciated mechanisms by which chromatin modifiers regulate the transcriptional activity of non-histone substrates to control cellular differentiation programs.

摘要

转录因子MyoD是骨骼肌分化的主要调节因子。主要参与组蛋白H3赖氨酸9二甲基化（H3K9me2）的酶G9a使MyoD甲基化，这一发现揭示了此前未被认识到的机制，即染色质修饰因子通过该机制调节非组蛋白底物的转录活性，以控制细胞分化程序。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4245/3632615/4604724fa09e/tran-3-215-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4245/3632615/2eb309ceb13f/tran-3-215-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4245/3632615/4604724fa09e/tran-3-215-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4245/3632615/2eb309ceb13f/tran-3-215-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4245/3632615/4604724fa09e/tran-3-215-g2.jpg

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本文引用的文献

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Genes Dev. 2012 Jan 1;26(1):37-42. doi: 10.1101/gad.173930.111.
2
Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation.赖氨酸甲基转移酶 G9a 甲基化转录因子 MyoD，调节骨骼肌分化。
Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):841-6. doi: 10.1073/pnas.1111628109. Epub 2012 Jan 3.
3
Polycomb protein Ezh1 promotes RNA polymerase II elongation.多梳蛋白 Ezh1 促进 RNA 聚合酶 II 的延伸。
组蛋白去乙酰化酶 4 通过靶向 P21 和 Sharp1 基因调控卫星细胞的增殖和分化。
Sci Rep. 2018 Feb 22;8(1):3448. doi: 10.1038/s41598-018-21835-7.
4
MiR-206 Attenuates Denervation-Induced Skeletal Muscle Atrophy in Rats Through Regulation of Satellite Cell Differentiation via TGF-β1, Smad3, and HDAC4 Signaling.微小RNA-206通过TGF-β1、Smad3和HDAC4信号通路调控卫星细胞分化减轻大鼠失神经诱导的骨骼肌萎缩
Med Sci Monit. 2016 Apr 7;22:1161-70. doi: 10.12659/msm.897909.
5
Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program.蛋白质组学和功能分析揭示了染色质读蛋白 SFMBT1 在调控表观遗传沉默和肌生成基因程序中的作用。
J Biol Chem. 2013 Mar 1;288(9):6238-47. doi: 10.1074/jbc.M112.429605. Epub 2013 Jan 24.
6
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Epigenetics. 2013 Jan;8(1):16-22. doi: 10.4161/epi.23331. Epub 2012 Dec 20.
7
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