Kumamoto Prefectural Institute of Public Health and Environmental Science, Kumamoto, Japan.
Arch Virol. 2012 Oct;157(10):1999-2003. doi: 10.1007/s00705-012-1387-7. Epub 2012 Jul 8.
Sapovirus (SaV) is an important pathogen that causes acute gastroenteritis in humans. Human SaV is highly diverse genetically and is classified into multiple genogroups and genotypes. At present, there is no clear evidence for gastroenteritis cases caused by re-infection with SaV. We found that two individuals were sequentially infected with SaVs of two different genogroups and had gastroenteritis after each infection, although in one of the subsequent cases, both SaV and norovirus were detected. We also found a genetic shift in SaVs from gastroenteritis outpatients in the same geographical location. Our results suggest that protective immunity may be at least genogroup-specific for SaV.
肠病毒（SaV）是一种重要的病原体，可导致人类急性肠胃炎。人类肠病毒在基因上具有高度多样性，可分为多个基因群和基因型。目前，尚无明确证据表明肠胃炎是由肠病毒再次感染引起的。我们发现两个个体先后感染了两种不同基因群的肠病毒，且每次感染后均发生肠胃炎，尽管在后一次感染中，同时检测到了肠病毒和诺如病毒。我们还发现同一地理位置的肠胃炎门诊患者的肠病毒发生了遗传转变。我们的研究结果表明，针对肠病毒的保护性免疫至少可能具有基因群特异性。
