支化聚乙二醇刷修饰的亲水性磁性纳米颗粒的合成及其用于 N-连接糖肽的选择性富集。
Synthesis of branched PEG brushes hybrid hydrophilic magnetic nanoparticles for the selective enrichment of N-linked glycopeptides.
机构信息
CAS Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Dalian 116023, China.
出版信息
Chem Commun (Camb). 2012 Aug 21;48(65):8138-40. doi: 10.1039/c2cc33600f. Epub 2012 Jul 9.
Hybrid Fe(3)O(4)@SiO(2)@PEG-Maltose MNPs were synthesized by SI-ATRP of branched PEG brushes on the surface and subsequent functionalization with hydrophilic maltose group, and the multifunctional materials were utilized for selective enrichment of N-linked glycopeptides from biological samples with high specifity, high sensitivity, and large binding capacity.
杂化 Fe(3)O(4)@SiO(2)@PEG-麦芽糖 MNPs 通过支化 PEG 刷在表面的 SI-ATRP 合成，随后用亲水性麦芽糖基团进行功能化，多功能材料用于从生物样品中选择性富集 N-连接糖肽，具有高特异性、高灵敏度和大结合容量。
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