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[弥漫性特发性骨肥厚:诊断与治疗的现状]

[Diffuse idiopathic skeletal hyperostosis: current aspects of diagnostics and therapy].

作者信息

Artner J, Leucht F, Cakir B, Reichel H, Lattig F

机构信息

Orthopädische Universitätsklinik Ulm am RKU, Oberer Eselsberg 45, 89081 Ulm, Deutschland.

出版信息

Orthopade. 2012 Nov;41(11):916-22. doi: 10.1007/s00132-012-1967-y.

Abstract

Diffuse idiopathic skeletal hyperostosis (DISH) is a common but often unrecognized systemic disorder observed mainly in the middle-aged and elderly population, characterized by ankylosing formations of the spine and ossifications of peripheral ligaments, tendons and joint capsule insertion points (entheses). Despite the increase of prevalence with age, the condition often remains undiagnosed. It can be an asymptomatic incidental radiographic finding but can also manifest in several multiorgan complications, such as back and neck pain, restriction of mobility of the spine, peripheral joint affection, dysphagia, dyspnea, foreign body sensation, hoarseness, neurologic manifestations due to compression of the spinal cord, hyperuricemia, obesity, hypercholesterinemia and resulting cardiovascular comorbidities, implicating a multidisciplinary approach. The following article presents a current overview of the condition.

摘要

弥漫性特发性骨肥厚(DISH)是一种常见但常未被认识的系统性疾病,主要见于中老年人群,其特征为脊柱的强直性骨化以及外周韧带、肌腱和关节囊附着点(起止点)的骨化。尽管患病率随年龄增长而增加,但该病常未被诊断。它可能是无症状的偶然影像学发现,但也可表现为多种多器官并发症,如颈背痛、脊柱活动受限、外周关节受累、吞咽困难、呼吸困难、异物感、声音嘶哑、脊髓受压所致的神经表现、高尿酸血症、肥胖、高胆固醇血症以及由此导致的心血管合并症,这意味着需要多学科方法。以下文章介绍了该病的当前概况。

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