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[氧化应激对男性不育的影响]

[Impact of oxidative stress on male infertility].

作者信息

Hampl R, Drábková P, Kanďár R, Stěpán J

机构信息

Centrum asistovane reprodukce Sanus, Pardubice.

出版信息

Ceska Gynekol. 2012 Jun;77(3):241-5.

PMID:22779727
Abstract

Reactive oxygen and nitrogen species (RONS) are necessary for the physiological function of sperm. Its concentration has to be kept on a level without the damage of cells. If this level is overdrawn sperm has pathological effect on many biological structures in the form of oxidative stress. Antioxidants have a key role for keeping of this balance. Oxidative stress is an important factor which causes problems with male fertility. The survey article is complexly concerned with the influence of RONS and antioxidants on male fertility. It outlines some possibilities of treatment and research on this actual issue of assisted reproduction.

摘要

活性氧和氮物种(RONS)对于精子的生理功能是必需的。其浓度必须保持在不会对细胞造成损伤的水平。如果这种水平被透支,精子会以氧化应激的形式对许多生物结构产生病理影响。抗氧化剂对于维持这种平衡起着关键作用。氧化应激是导致男性生育问题的一个重要因素。这篇综述文章全面探讨了RONS和抗氧化剂对男性生育能力的影响。它概述了针对这一辅助生殖实际问题的一些治疗和研究可能性。

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