Institute of Biochemical Engineering, Technische Universität Braunschweig, Gaußstraße 17, Braunschweig, Germany.
Biotechnol Lett. 2012 Nov;34(11):1975-82. doi: 10.1007/s10529-012-0997-1. Epub 2012 Jul 11.
Filamentous microorganisms are important work horses in industrial biotechnology and supply enzymes, antibiotics, pharmaceuticals, bulk and fine chemicals. Here we highlight recent findings on the use of microparticles in the cultivation of filamentous bacteria and fungi, with the aim of enabling a more precise control of their morphology towards better production performance. First examples reveal a broad application range of microparticle based processes, since multiple filamentous organisms are controllable in their growth characteristics and respond by enhanced product formation.
丝状微生物是工业生物技术中的重要工具，它们提供酶、抗生素、药物、大宗和精细化学品。在这里，我们重点介绍了最近在丝状细菌和真菌培养中使用微颗粒的发现，目的是能够更精确地控制它们的形态，以提高生产性能。最初的例子表明，基于微颗粒的工艺具有广泛的应用范围，因为多种丝状生物的生长特性可以得到控制，并且通过增强产物形成来响应。
