尿N(1),N(12)-二乙酰精胺（DiAcSpm）水平作为结直肠癌患者肿瘤标志物的临床应用价值。
The clinical usefulness of urinary N(1),N(12)-diacetylspermine (DiAcSpm) levels as a tumor marker in patients with colorectal cancer.
作者信息
Nakayama Yoshifumi, Torigoe Takayuki, Minagawa Noritaka, Yamaguchi Koji
机构信息
Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kita-Kyushu, Fukuoka 807-8555, Japan.
出版信息
Oncol Lett. 2012 May;3(5):970-974. doi: 10.3892/ol.2012.625. Epub 2012 Feb 29.
The aim of this study was to evaluate the usefulness of urinary N(1),N(12)-diacetylspermine (DiAcSpm) measured by the colloidal gold aggregation method as a tumor marker for colorectal cancer (CRC). The preoperative urine of 113 CRC patients was collected, and the urinary DiAcSpm was measured by a reagent kit for DiAcSpm determination based on colloidal gold aggregation using automatic biochemical analyzers. The urinary DiAcSpm levels significantly correlated with distant metastasis and Tumor-Node-Metastasis (TNM) stage. The positive rates of urinary DiAcSpm were significantly higher than those of serum carcinoembryonic antigen (CEA) or cancer antigen 19-9 (CA19-9) in stages 0+I, II, III and IV. The positive rates of urinary DiAcSpm were also significantly higher than those of serum CEA or CA19-9 in the early and advanced CRC groups according to the Japan Classification of Colorectal Cancer. Therefore, urinary DiAcSpm, measured by a reagent kit for DiAcSpm determination based on colloidal gold aggregation, may be useful as a non-invasive tumor marker in patients with CRC.
本研究旨在评估采用胶体金凝集法测定的尿N(1),N(12)-二乙酰精胺（DiAcSpm）作为结直肠癌（CRC）肿瘤标志物的实用性。收集了113例CRC患者的术前尿液，并使用基于胶体金凝集的DiAcSpm检测试剂盒，通过自动生化分析仪测定尿DiAcSpm。尿DiAcSpm水平与远处转移及肿瘤-淋巴结-转移（TNM）分期显著相关。在0+I期、II期、III期和IV期，尿DiAcSpm的阳性率显著高于血清癌胚抗原（CEA）或癌抗原19-9（CA19-9）。根据日本结直肠癌分类，在早期和晚期CRC组中，尿DiAcSpm的阳性率也显著高于血清CEA或CA19-9。因此，采用基于胶体金凝集的DiAcSpm检测试剂盒测定的尿DiAcSpm，可能作为CRC患者的一种非侵入性肿瘤标志物。
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