Tan I B, Balm A J, Snow G B, Drexhage H A
Department of Otolaryngology/Head and Neck Surgery, Free University Hospital, Amsterdam, The Netherlands.
Eur Arch Otorhinolaryngol. 1990;247(6):387-90. doi: 10.1007/BF00179016.
The chemotactic responsiveness of mononuclear phagocytes has often been found defective in patients with various malignancies. We have previously reported a defective chemotactic responsiveness in patients with head and neck cancer. Low-molecular-weight factors (LMWFs) have been isolated from tumors and can be held responsible for the inhibitory effect on monocyte chemotactic responsiveness. It is an intriguing new finding that these LMWFs can be neutralized by antibodies reactive to P15E, a structural envelope protein of murine leukemia retroviruses. In this report we describe a relatively easy and rapid method for the detection of immunosuppressive P15E-like factors in the sera of patients with head and neck cancer. The test is based on the monocyte polarization assay. Although only nine head and neck cancer patients were included in this study, the findings indicate that the test might be of value for clinical application. An early detection of a recurrence after treatment might be possible by the finding of a reappearance of the P15E-like factors in patients' sera during follow-up.
在患有各种恶性肿瘤的患者中，经常发现单核吞噬细胞的趋化反应性存在缺陷。我们之前报道过头颈癌患者存在趋化反应性缺陷。低分子量因子（LMWFs）已从肿瘤中分离出来，可能是对单核细胞趋化反应性产生抑制作用的原因。一个有趣的新发现是，这些LMWFs可被与P15E反应的抗体中和，P15E是鼠白血病逆转录病毒的一种结构包膜蛋白。在本报告中，我们描述了一种相对简便快速的方法，用于检测头颈癌患者血清中免疫抑制性P15E样因子。该检测基于单核细胞极化分析。尽管本研究仅纳入了9名头颈癌患者，但研究结果表明该检测可能具有临床应用价值。通过在随访期间发现患者血清中P15E样因子再次出现，有可能早期检测出治疗后的复发情况。
