Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.
J Korean Med Sci. 2012 Jul;27(7):744-7. doi: 10.3346/jkms.2012.27.7.744. Epub 2012 Jun 29.
Osteoporosis is a widely recognized health problem in postmenopausal women. Osteoporotic fractures reduce independency, limit daily living activities, and increase the mortality rate. Epidemiological studies have demonstrated that low handgrip strength is a risk factor for functional limitations and disabilities, and all-cause mortality. We investigated the relationship between handgrip strength and bone mineral density (BMD) of the spine, femur neck, and total hip, as well the relationship between handgrip strength and previous fragility fractures in 337 healthy postmenopausal Korean women (mean age of 59.5 ± 6.8 yr) who were free of diseases or medications affecting bone metabolism. Age and handgrip strength were associated with BMD of the spine, femur neck, and total hip in multiple regression models. Low handgrip strength (odds ratio [OR], 0.925; range, 0.877 to 0.975; P = 0.004) and low femur neck BMD (OR, 0.019; range, 0.001 to 0.354; P = 0.008) were independent predictors of previous fragility fractures in a multiple regression model. Our results demonstrate that low handgrip strength is associated with low BMD of the spine, femur neck, and total hip, and with increased risk of previous fragility fractures.
骨质疏松症是绝经后妇女中广泛存在的健康问题。骨质疏松性骨折会降低独立性，限制日常生活活动，并增加死亡率。流行病学研究表明，握力低是功能受限和残疾以及全因死亡率的一个危险因素。我们研究了 337 名健康绝经后韩国女性（平均年龄 59.5±6.8 岁）的握力与脊柱、股骨颈和全髋关节骨密度（BMD）之间的关系，以及握力与既往脆性骨折之间的关系，这些女性没有影响骨代谢的疾病或药物。在多元回归模型中，年龄和握力与脊柱、股骨颈和全髋关节的 BMD 相关。握力低（比值比 [OR]，0.925；范围，0.877 至 0.975；P=0.004）和股骨颈 BMD 低（OR，0.019；范围，0.001 至 0.354；P=0.008）是既往脆性骨折的独立预测因素。我们的结果表明，握力低与脊柱、股骨颈和全髋关节的 BMD 降低以及既往脆性骨折风险增加相关。
