Laboratoire de Neurophysiologie, Faculté de Médecine, Université Libre de Bruxelles Bruxelles, Belgium.
Front Mol Neurosci. 2012 Jul 10;5:78. doi: 10.3389/fnmol.2012.00078. eCollection 2012.
Calcium binding proteins, such as parvalbumin (PV), are abundantly expressed in distinctive patterns in the central nervous system but their physiological function remains poorly understood. Notably, at the level of the striatum, where PV is only expressed in the fast-spiking (FS) interneurons. FS interneurons form an inhibitory network modulating the output of the striatum by synchronizing medium-sized spiny neurons (MSN). So far the existing conductance-based computational models for FS neurons did not allow the study of the coupling between PV concentration and electrical activity. In the present paper, we propose a new mathematical model for the striatal FS interneurons that includes apamin-sensitive small conductance Ca(2+)-dependent K(+) channels (SK) and the presence of a calcium buffer. Our results show that a variation in the concentration of PV can modulate substantially the intrinsic excitability of the FS interneurons and therefore may be involved in the information processing at the striatal level.
钙结合蛋白，如副肌球蛋白 (PV)，在中枢神经系统中以独特的模式大量表达，但它们的生理功能仍知之甚少。值得注意的是，在纹状体水平，只有快速发射 (FS) 中间神经元中表达 PV。FS 中间神经元通过同步中型棘突神经元 (MSN) 形成抑制性网络来调节纹状体的输出。到目前为止，现有的基于 FS 神经元的电导率计算模型不允许研究 PV 浓度与电活动之间的耦合。在本文中，我们提出了一个新的纹状体 FS 中间神经元的数学模型，其中包括阿帕米敏感的小电导钙依赖性钾 (SK) 通道和钙缓冲的存在。我们的结果表明，PV 浓度的变化可以显著调节 FS 中间神经元的内在兴奋性，因此可能参与了纹状体水平的信息处理。
