Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.
Cancer Cell. 2012 Jul 10;22(1):5-6. doi: 10.1016/j.ccr.2012.06.006.
DNA damage can arrest replication forks during S phase. Failure to stabilize and restart arrested forks results in fork collapse and genomic instability. In this issue of Cancer Cell, Schlacher et al. show that the Fanconi anemia and BRCA2 tumor suppressor pathways cooperate to protect stalled replication forks from degradation.
DNA 损伤可在 S 期使复制叉停滞。如果不能稳定并重新启动停滞的叉，就会导致叉崩溃和基因组不稳定。在本期《癌细胞》中，Schlacher 等人表明，范可尼贫血和 BRCA2 肿瘤抑制途径合作，保护停滞的复制叉免受降解。
