癌症与炎症：每天一片阿司匹林，远离癌症。
Cancer and inflammation: an aspirin a day keeps the cancer at bay.
机构信息
Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany.
出版信息
Curr Biol. 2012 Jul 10;22(13):R522-5. doi: 10.1016/j.cub.2012.05.037.
Abstract
Live imaging of the interactions between oncogene-transformed cells and leukocytes in zebrafish reveals that PGE(2) promotes the survival and proliferation of cancer cells. Non-steroid anti-inflammatory drugs, like aspirin, are the effective inhibitors of PGE(2) production and could be used with other anti-tumor agents in the treatment of cancer.
摘要
在斑马鱼体内实时观察癌基因转化细胞与白细胞的相互作用，揭示 PGE（2）可促进癌细胞的存活和增殖。非甾体类抗炎药，如阿司匹林，是 PGE（2）产生的有效抑制剂，可与其他抗肿瘤药物联合用于癌症的治疗。
相似文献
1
Cancer and inflammation: an aspirin a day keeps the cancer at bay.癌症与炎症：每天一片阿司匹林，远离癌症。
Curr Biol. 2012 Jul 10;22(13):R522-5. doi: 10.1016/j.cub.2012.05.037.
2
Live imaging of tumor initiation in zebrafish larvae reveals a trophic role for leukocyte-derived PGE₂.斑马鱼幼鱼中肿瘤起始的实时成像揭示了白细胞衍生的 PGE₂ 的营养作用。
Curr Biol. 2012 Jul 10;22(13):1253-9. doi: 10.1016/j.cub.2012.05.010. Epub 2012 May 31.
3
Ibuprofen reduces zebrafish PGE(2) levels but steroid hormone levels and reproductive parameters are not affected.布洛芬降低斑马鱼 PGE（2）水平，但类固醇激素水平和生殖参数不受影响。
Comp Biochem Physiol C Toxicol Pharmacol. 2013 Mar;157(2):251-7. doi: 10.1016/j.cbpc.2012.12.001. Epub 2012 Dec 13.
4
Prostaglandins and cancer.前列腺素与癌症
Gut. 2006 Jan;55(1):115-22. doi: 10.1136/gut.2004.047100. Epub 2005 Aug 23.
5
3-OH flavone inhibition of epidermal growth factor-induced proliferaton through blocking prostaglandin E2 production.3-羟基黄酮通过阻断前列腺素E2的产生来抑制表皮生长因子诱导的增殖。
Int J Cancer. 2004 Feb 10;108(4):502-10. doi: 10.1002/ijc.11581.
6
Release of cysteinyl leukotrienes with aspirin stimulation and the effect of prostaglandin E(2) on this release from peripheral blood leucocytes in aspirin-induced asthmatic patients.阿司匹林激发试验诱导的哮喘患者外周血白细胞半胱氨酰白三烯的释放及前列腺素E₂对此释放的影响
Clin Exp Allergy. 2001 Oct;31(10):1615-22. doi: 10.1046/j.1365-2222.2001.01074.x.
7
Effect of aspirin, paracetamol and their nitric oxide donating derivatives on exudate cytokine and PGE2 production in zymosan-induced air pouch inflammation in rats.阿司匹林、对乙酰氨基酚及其一氧化氮供体衍生物对大鼠酵母聚糖诱导气囊炎症中渗出液细胞因子和前列腺素E2产生的影响。
Eur J Pharmacol. 2007 Apr 30;561(1-3):220-5. doi: 10.1016/j.ejphar.2007.01.033. Epub 2007 Feb 1.
8
Effect of Low-dose and Standard-dose Aspirin on PGE Biosynthesis Among Individuals with Colorectal Adenomas: A Randomized Clinical Trial.低剂量和标准剂量阿司匹林对结直肠腺瘤患者 PGE 生物合成的影响：一项随机临床试验。
Cancer Prev Res (Phila). 2020 Oct;13(10):877-888. doi: 10.1158/1940-6207.CAPR-20-0216. Epub 2020 Jul 27.
9
PGE suppresses excessive anti-IgE induced cysteinyl leucotrienes production in mast cells of patients with aspirin exacerbated respiratory disease.前列腺素E抑制阿司匹林加重性呼吸系统疾病患者肥大细胞中过量抗IgE诱导的半胱氨酰白三烯生成。
Allergy. 2007 Jun;62(6):620-7. doi: 10.1111/j.1398-9995.2007.01364.x.
10
Prostaglandin E2 blocks menadione-induced apoptosis through the Ras/Raf/Erk signaling pathway in promonocytic leukemia cell lines.前列腺素 E2 通过 Ras/Raf/Erk 信号通路阻断甲萘醌诱导的单核细胞白血病细胞系细胞凋亡。
Mol Cells. 2012 Apr;33(4):371-8. doi: 10.1007/s10059-012-2293-2. Epub 2012 Mar 23.
引用本文的文献
1
PGE2-JNK signaling axis non-canonically promotes Gli activation by protecting Gli2 from ubiquitin-proteasomal degradation.PGE2-JNK 信号轴通过保护 Gli2 免受泛素蛋白酶体降解，非经典地促进 Gli 的激活。
Cell Death Dis. 2021 Jul 15;12(7):707. doi: 10.1038/s41419-021-03995-z.
2
A novel zebrafish intestinal tumor model reveals a role for -dependent tumor-liver crosstalk in causing adverse effects on the host.一种新型斑马鱼肠道肿瘤模型揭示了 -dependent 肿瘤-肝脏串扰在宿主产生不良影响中的作用。
Dis Model Mech. 2018 May 3;11(8):dmm032383. doi: 10.1242/dmm.032383.
3
A Carrier-Free Nanostructure Based on Platinum(IV) Prodrug Enhances Cellular Uptake and Cytotoxicity.基于顺铂前药的无载体纳米结构增强细胞摄取和细胞毒性。
Mol Pharm. 2018 Apr 2;15(4):1724-1728. doi: 10.1021/acs.molpharmaceut.8b00070. Epub 2018 Mar 14.
4
Advances in genomics of bony fish.硬骨鱼类基因组学的进展。
Brief Funct Genomics. 2014 Mar;13(2):144-56. doi: 10.1093/bfgp/elt046. Epub 2013 Nov 29.
5
Aspirin and its related non-steroidal anti-inflammatory drugs.阿司匹林及其相关的非甾体抗炎药。
Libyan J Med. 2013 Jul 1;8(1):21569. doi: 10.3402/ljm.v8i0.21569.
6
Systems biology of cancer: entropy, disorder, and selection-driven evolution to independence, invasion and "swarm intelligence".癌症的系统生物学：熵、无序以及向独立、侵袭和“群体智能”的选择驱动进化
Cancer Metastasis Rev. 2013 Dec;32(3-4):403-21. doi: 10.1007/s10555-013-9431-y.
7
Obesity-driven inflammation and cancer risk: role of myeloid derived suppressor cells and alternately activated macrophages.肥胖驱动的炎症与癌症风险：髓系来源抑制细胞和交替激活的巨噬细胞的作用。
Am J Cancer Res. 2013;3(1):21-33. Epub 2013 Jan 18.
本文引用的文献
1
Live imaging of tumor initiation in zebrafish larvae reveals a trophic role for leukocyte-derived PGE₂.斑马鱼幼鱼中肿瘤起始的实时成像揭示了白细胞衍生的 PGE₂ 的营养作用。
Curr Biol. 2012 Jul 10;22(13):1253-9. doi: 10.1016/j.cub.2012.05.010. Epub 2012 May 31.
2
Prostaglandins in cancer cell adhesion, migration, and invasion.前列腺素在癌细胞黏附、迁移和侵袭中的作用
Int J Cell Biol. 2012;2012:723419. doi: 10.1155/2012/723419. Epub 2012 Feb 29.
3
Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma.自分泌前列腺素 E2 信号促进儿童神经母细胞瘤肿瘤细胞的存活和增殖。
PLoS One. 2012;7(1):e29331. doi: 10.1371/journal.pone.0029331. Epub 2012 Jan 19.
4
Prostaglandin E2 promotes intestinal tumor growth via DNA methylation.前列腺素 E2 通过 DNA 甲基化促进肠道肿瘤生长。
Nat Med. 2012 Jan 22;18(2):224-6. doi: 10.1038/nm.2608.
5
Innate inflammation and cancer: Is it time for cancer prevention?先天性炎症与癌症：是时候进行癌症预防了吗？
F1000 Med Rep. 2011;3:11. doi: 10.3410/M3-11. Epub 2011 Jun 1.
6
Live imaging of innate immune cell sensing of transformed cells in zebrafish larvae: parallels between tumor initiation and wound inflammation.在斑马鱼幼虫中对转化细胞的先天免疫细胞感应的活体成像：肿瘤起始与创伤炎症之间的平行关系。
PLoS Biol. 2010 Dec 14;8(12):e1000562. doi: 10.1371/journal.pbio.1000562.
7
Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish.致癌性 HRAS 的 Kita 驱动表达导致斑马鱼中黑色素瘤的早期发病和高穿透性。
PLoS One. 2010 Dec 10;5(12):e15170. doi: 10.1371/journal.pone.0015170.
8
Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials.每日服用阿司匹林对癌症导致的长期死亡风险的影响：来自随机试验的个体患者数据的分析。
Lancet. 2011 Jan 1;377(9759):31-41. doi: 10.1016/S0140-6736(10)62110-1. Epub 2010 Dec 6.
9
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.Wnt/β-catenin 通路对于 AML 中白血病干细胞的发育是必需的。
Science. 2010 Mar 26;327(5973):1650-3. doi: 10.1126/science.1186624.
10
Eicosanoids and cancer.类二十烷酸和癌症。
Nat Rev Cancer. 2010 Mar;10(3):181-93. doi: 10.1038/nrc2809. Epub 2010 Feb 19.
Zotero 插件