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本文引用的文献

1
Live imaging of tumor initiation in zebrafish larvae reveals a trophic role for leukocyte-derived PGE₂.斑马鱼幼鱼中肿瘤起始的实时成像揭示了白细胞衍生的 PGE₂ 的营养作用。
Curr Biol. 2012 Jul 10;22(13):1253-9. doi: 10.1016/j.cub.2012.05.010. Epub 2012 May 31.
2
Prostaglandins in cancer cell adhesion, migration, and invasion.前列腺素在癌细胞黏附、迁移和侵袭中的作用
Int J Cell Biol. 2012;2012:723419. doi: 10.1155/2012/723419. Epub 2012 Feb 29.
3
Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma.自分泌前列腺素 E2 信号促进儿童神经母细胞瘤肿瘤细胞的存活和增殖。
PLoS One. 2012;7(1):e29331. doi: 10.1371/journal.pone.0029331. Epub 2012 Jan 19.
4
Prostaglandin E2 promotes intestinal tumor growth via DNA methylation.前列腺素 E2 通过 DNA 甲基化促进肠道肿瘤生长。
Nat Med. 2012 Jan 22;18(2):224-6. doi: 10.1038/nm.2608.
5
Innate inflammation and cancer: Is it time for cancer prevention?先天性炎症与癌症:是时候进行癌症预防了吗?
F1000 Med Rep. 2011;3:11. doi: 10.3410/M3-11. Epub 2011 Jun 1.
6
Live imaging of innate immune cell sensing of transformed cells in zebrafish larvae: parallels between tumor initiation and wound inflammation.在斑马鱼幼虫中对转化细胞的先天免疫细胞感应的活体成像:肿瘤起始与创伤炎症之间的平行关系。
PLoS Biol. 2010 Dec 14;8(12):e1000562. doi: 10.1371/journal.pbio.1000562.
7
Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish.致癌性 HRAS 的 Kita 驱动表达导致斑马鱼中黑色素瘤的早期发病和高穿透性。
PLoS One. 2010 Dec 10;5(12):e15170. doi: 10.1371/journal.pone.0015170.
8
Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials.每日服用阿司匹林对癌症导致的长期死亡风险的影响:来自随机试验的个体患者数据的分析。
Lancet. 2011 Jan 1;377(9759):31-41. doi: 10.1016/S0140-6736(10)62110-1. Epub 2010 Dec 6.
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The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.Wnt/β-catenin 通路对于 AML 中白血病干细胞的发育是必需的。
Science. 2010 Mar 26;327(5973):1650-3. doi: 10.1126/science.1186624.
10
Eicosanoids and cancer.类二十烷酸和癌症。
Nat Rev Cancer. 2010 Mar;10(3):181-93. doi: 10.1038/nrc2809. Epub 2010 Feb 19.

癌症与炎症:每天一片阿司匹林,远离癌症。

Cancer and inflammation: an aspirin a day keeps the cancer at bay.

机构信息

Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany.

出版信息

Curr Biol. 2012 Jul 10;22(13):R522-5. doi: 10.1016/j.cub.2012.05.037.

DOI:10.1016/j.cub.2012.05.037
PMID:22789999
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6022370/
Abstract

Live imaging of the interactions between oncogene-transformed cells and leukocytes in zebrafish reveals that PGE(2) promotes the survival and proliferation of cancer cells. Non-steroid anti-inflammatory drugs, like aspirin, are the effective inhibitors of PGE(2) production and could be used with other anti-tumor agents in the treatment of cancer.

摘要

在斑马鱼体内实时观察癌基因转化细胞与白细胞的相互作用,揭示 PGE(2)可促进癌细胞的存活和增殖。非甾体类抗炎药,如阿司匹林,是 PGE(2)产生的有效抑制剂,可与其他抗肿瘤药物联合用于癌症的治疗。