Ves v 5可在对黄蜂毒液无可检测到的特异性IgE的患者中确诊，且欧洲可能存在Api m 1致敏的南北差异。 - Suppr

Ves v 5 can establish the diagnosis in patients without detectable specific IgE to wasp venom and a possible north-south difference in Api m 1 sensitization in Europe.

作者信息

Sturm Gunter J, Biló Maria Beatrice, Bonadonna Patrizia, Hemmer Wolfgang, Caruso Beatrice, Bokanovic Danijela, Aberer Werner

出版信息

J Allergy Clin Immunol. 2012 Sep;130(3):817; author reply 818-9. doi: 10.1016/j.jaci.2012.05.047. Epub 2012 Jul 11.

DOI:10.1016/j.jaci.2012.05.047

PMID:22795371

Abstract

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Ves v 5 can establish the diagnosis in patients without detectable specific IgE to wasp venom and a possible north-south difference in Api m 1 sensitization in Europe.Ves v 5可在对黄蜂毒液无可检测到的特异性IgE的患者中确诊，且欧洲可能存在Api m 1致敏的南北差异。

J Allergy Clin Immunol. 2012 Sep;130(3):817; author reply 818-9. doi: 10.1016/j.jaci.2012.05.047. Epub 2012 Jul 11.

High sensitivity of CAP-FEIA rVes v 5 and rVes v 1 for diagnosis of Vespula venom allergy.CAP-FEIA rVes v 5和rVes v 1对黄蜂毒液过敏诊断的高敏感性。

J Allergy Clin Immunol. 2012 May;129(5):1406-8. doi: 10.1016/j.jaci.2011.12.975. Epub 2012 Jan 24.

IgE to recombinant allergens Api m 1, Ves v 1, and Ves v 5 distinguish double sensitization from crossreaction in venom allergy.IgE 对重组过敏原 Api m 1、Ves v 1 和 Ves v 5 的反应可区分毒液过敏中的双重致敏与交叉反应。

Allergy. 2012 Aug;67(8):1069-73. doi: 10.1111/j.1398-9995.2012.02847.x. Epub 2012 Jun 8.

Recombinant allergen-based IgE testing to distinguish bee and wasp allergy.基于重组变应原的 IgE 检测以区分蜜蜂和黄蜂过敏。

J Allergy Clin Immunol. 2010 Jun;125(6):1300-1307.e3. doi: 10.1016/j.jaci.2010.03.017. Epub 2010 May 13.

Hymenoptera venom allergy: analysis of double positivity to honey bee and Vespula venom by estimation of IgE antibodies to species-specific major allergens Api m1 and Ves v5.膜翅目毒液过敏：通过检测针对物种特异性主要过敏原Api m1和Ves v5的IgE抗体，分析对蜜蜂和黄蜂毒液的双重阳性反应。

Allergy. 2009 Apr;64(4):543-8. doi: 10.1111/j.1398-9995.2008.01794.x. Epub 2008 Dec 18.

Individual hymenoptera venom compounds induce upregulation of the basophil activation marker ectonucleotide pyrophosphatase/phosphodiesterase 3 (CD203c) in sensitized patients.个别膜翅目毒液化合物可诱导致敏患者嗜碱性粒细胞活化标志物外核苷酸焦磷酸酶/磷酸二酯酶3（CD203c）上调。

Int Arch Allergy Immunol. 2002 Oct;129(2):160-8. doi: 10.1159/000065875.

Identification, recombinant expression, and characterization of the 100 kDa high molecular weight Hymenoptera venom allergens Api m 5 and Ves v 3.蜂类毒液过敏原 Api m 5 和 Ves v 3 的 100kDa 高分子量的鉴定、重组表达和特性分析。

J Immunol. 2010 May 1;184(9):5403-13. doi: 10.4049/jimmunol.0803709. Epub 2010 Mar 26.

Diagnostic precision of component-resolved vs. extract-based in vitro diagnosis of hymenoptera venom allergy: effects on clinical management.膜翅目毒液过敏的组分分辨体外诊断与基于提取物的体外诊断的诊断准确性：对临床管理的影响。

J Dtsch Dermatol Ges. 2017 May;15(5):507-515. doi: 10.1111/ddg.13240.

Component-resolved diagnosis of wasp (yellow jacket) venom allergy.蜂（黄蜂）毒液过敏的成分解析诊断。

Clin Exp Allergy. 2013 Feb;43(2):255-61. doi: 10.1111/cea.12057.

Improved recombinant Api m 1- and Ves v 5-based IgE testing to dissect bee and yellow jacket allergy and their correlation with the severity of the sting reaction.改进基于重组变应原Api m 1和Ves v 5的IgE检测，以区分蜜蜂和黄蜂过敏及其与蜇伤反应严重程度的相关性。

Clin Exp Allergy. 2016 Apr;46(4):621-30. doi: 10.1111/cea.12639.

引用本文的文献

Biomarkers for the Molecular Diagnosis of IgE-Mediated Hymenoptera Venom Allergy in Clinical Practice.临床实践中用于IgE介导的膜翅目毒液过敏分子诊断的生物标志物。

Int J Mol Sci. 2024 Dec 31;26(1):270. doi: 10.3390/ijms26010270.

Hymenoptera venom allergy in children.儿童蜂类毒液过敏

Ital J Pediatr. 2024 Dec 20;50(1):262. doi: 10.1186/s13052-024-01731-9.

The role of molecular diagnosis in anaphylactic patients with dual or triple-sensitization to Hymenoptera venoms.分子诊断在对膜翅目毒液双重或三重致敏的过敏患者中的作用。

Allergy Asthma Clin Immunol. 2024 Mar 23;20(1):22. doi: 10.1186/s13223-024-00885-9.

Revealing clinically relevant specific IgE sensitization patterns in Hymenoptera venom allergy with dimension reduction and clustering.通过降维和聚类揭示膜翅目毒液过敏中临床相关的特异性IgE致敏模式。

World Allergy Organ J. 2023 Sep 30;16(10):100820. doi: 10.1016/j.waojou.2023.100820. eCollection 2023 Oct.

Precision Medicine in Hymenoptera Venom Allergy: Diagnostics, Biomarkers, and Therapy of Different Endotypes and Phenotypes.膜翅目毒液过敏的精准医学：不同表型和内型的诊断、生物标志物和治疗。

Front Immunol. 2020 Oct 22;11:579409. doi: 10.3389/fimmu.2020.579409. eCollection 2020.

Antigen 5 Allergens of Hymenoptera Venoms and Their Role in Diagnosis and Therapy of Venom Allergy.蜂类毒液的抗原 5 过敏原及其在毒液过敏诊断和治疗中的作用。

Curr Allergy Asthma Rep. 2020 Jul 9;20(10):58. doi: 10.1007/s11882-020-00954-0.

A WAO - ARIA - GALEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020.WAO - ARIA - GALEN关于基于分子的过敏诊断的共识文件（PAMD@）：2020年更新版

World Allergy Organ J. 2020 Mar 7;13(2):100091. doi: 10.1016/j.waojou.2019.100091. eCollection 2020 Feb.

Allergy and sensitization to Hymenoptera venoms in unreferred adults with a high risk of sting exposure.未转诊的有高蜂蜇暴露风险的成年人中对膜翅目毒液的过敏和致敏反应。

World Allergy Organ J. 2019 Jun 28;12(7):100039. doi: 10.1016/j.waojou.2019.100039. eCollection 2019.

Component resolved diagnostics for hymenoptera venom allergy.膜翅目毒液过敏的组分分辨诊断

Curr Opin Allergy Clin Immunol. 2017 Oct;17(5):363-372. doi: 10.1097/ACI.0000000000000390.

Diagnostics in Hymenoptera venom allergy: current concepts and developments with special focus on molecular allergy diagnostics.膜翅目毒液过敏的诊断：当前概念与进展，特别关注分子过敏诊断

Allergo J Int. 2017;26(3):93-105. doi: 10.1007/s40629-017-0014-2. Epub 2017 Apr 11.

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Ves v 5 can establish the diagnosis in patients without detectable specific IgE to wasp venom and a possible north-south difference in Api m 1 sensitization in Europe.

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