MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, UK.
Adv Nutr. 2012 Jul 1;3(4):583-91. doi: 10.3945/an.111.001230.
The resurgence in interest and concern regarding the potentially malign interactions between iron administration and malaria infections, especially in young children and pregnant women, has generated a research agenda that is both broad and deep. This paper highlights some of the key questions under 5 headings: basic science; clinical science and epidemiology; technological developments; country level planning; and global policy. At a time of unparalleled progress in basic science, which is illuminating the mechanisms by which iron interacts with infectious organisms, it is concluded that there are good medium-term prospects for achieving policy breakthroughs based on a secure foundation of disease-nutrient interactions. However, it is also stressed that there is much that can be done in the interim, especially in relation to health systems and implementation research that can empower systems to integrate iron interventions with programs for malaria prevention, surveillance, and treatment.
人们对铁剂治疗与疟疾感染之间可能存在的不良相互作用的兴趣和关注再次兴起，尤其是在幼儿和孕妇中，这引发了一个广泛而深入的研究议程。本文重点讨论了以下 5 个方面的关键问题：基础科学、临床科学和流行病学、技术发展、国家规划以及全球政策。在基础科学取得前所未有的进展的时代，这些进展揭示了铁与感染性生物体相互作用的机制，我们得出的结论是，基于疾病-营养相互作用的坚实基础，实现政策突破的中期前景良好。然而，我们也强调，在这期间仍有许多工作要做，特别是在卫生系统和实施研究方面，可以使系统能够将铁干预措施与疟疾预防、监测和治疗方案相结合。
