National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 633-165, Gaegeum-dong, Busanjin-gu, Busan 614-735, Korea.
Nutr Res Pract. 2012 Jun;6(3):226-31. doi: 10.4162/nrp.2012.6.3.226. Epub 2012 Jun 30.
The purpose of the study was to assess the effects of a 12 weeks aged garlic extract (AGE) regimen with regular exercise on cardiovascular disease (CVD) risk in postmenopausal women. A total of 30 postmenopausal women (54.4 ± 5.4 years) were randomly divided into the following four groups: Placebo (Placebo; n = 6), AGE intake (AGEI; n = 8), exercise and placebo (Ex + Placebo; n = 8), exercise and AGE (Ex + AGE; n = 8) groups. The AGE group consume 80 mg per day, and exercise groups performed moderate exercise (aerobic and resistance) three times per week. After 12 weeks of treatment, body composition, lipid profile, and CVD risk factors were analyzed. Body weight was significantly decreased in AGEI, Ex + Placebo, and Ex + AGE groups compared to baseline. Body fat % was significantly decreased in the AGEI and Ex + Placebo groups. Body mass index (BMI) was significantly decreased in the AGEI, Ex + Placebo, and Ex + AGE groups. Fat-free mass was significantly decreased in the AGEI group. Total cholesterol (TC) was significantly lower in the Ex + Placebo compared to the Placebo group. AGE supplementation or exercise effectively reduced low-density lipoprotein (LDL-C). Triglyceride (TG) was significantly increased in the AGEI group. Malondialdehyde (MDA) levels were significantly decreased in the AGEI, Ex + Placebo, and Ex + AGE compared to the placebo group. AGE supplementation reduced homocysteine levels regardless of whether the women also exercised. The present results suggest that AGE supplementation reduces cardiovascular risk factors independently of exercise in postmenopausal women.
本研究旨在评估 12 周龄大蒜提取物（AGE）方案与常规运动对绝经后女性心血管疾病（CVD）风险的影响。共有 30 名绝经后妇女（54.4 ± 5.4 岁）被随机分为以下四组：安慰剂组（Placebo；n = 6）、AGE 摄入组（AGEI；n = 8）、运动和安慰剂组（Ex + Placebo；n = 8）、运动和 AGE 组（Ex + AGE；n = 8）。AGE 组每天摄入 80 毫克，运动组每周进行三次中等强度的运动（有氧运动和抗阻运动）。经过 12 周的治疗，分析了身体成分、血脂谱和 CVD 危险因素。与基线相比，AGEI、Ex + Placebo 和 Ex + AGE 组的体重均显著下降。AGEI 和 Ex + Placebo 组的体脂百分比显著下降。体重指数（BMI）在 AGEI、Ex + Placebo 和 Ex + AGE 组显著下降。AGEI 组的去脂体重显著下降。与安慰剂组相比，Ex + Placebo 组的总胆固醇（TC）显著降低。AGE 补充或运动有效地降低了低密度脂蛋白胆固醇（LDL-C）。AGEI 组的甘油三酯（TG）显著升高。AGEI、Ex + Placebo 和 Ex + AGE 组的丙二醛（MDA）水平与安慰剂组相比均显著降低。AGE 补充剂降低了同型半胱氨酸水平，而不论女性是否运动。本研究结果表明，AGE 补充剂可降低绝经后女性的心血管危险因素，而与运动无关。
