Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor, 43400 Serdang, Malaysia.
Evid Based Complement Alternat Med. 2012;2012:838604. doi: 10.1155/2012/838604. Epub 2012 Jul 1.
The effect of C. odontophyllum (CO) fruit parts was investigated in hypercholesterolemic rabbits. Forty-nine rabbits, which were randomly divided into seven groups of seven animals (n = 7), received a diet containing different parts of CO fruit parts for 8 weeks. The groups were as follows: (1) normal diet: NC group and (2) hypercholesterolemic diet: PC, HS (10 mg/kg/day simvastatin), HPO (20 g kg(-1) oil extracted from the pulp of CO), HKO (20 g kg(-1) oil extracted from the kernel of CO), HF (50 g kg(-1) fullfat pulp of CO), and HD (50 g kg(-1) defatted pulp of CO). Among these groups, rabbits receiving defatted pulp of CO showed the greatest cholesterol lowering effect as it had reduced plasma LDL-C, TC, and thiobarbiturate reactive substance (TBARS) levels as well as atherosclerotic plaques. The presence of high dietary fiber and antioxidants activity are potential factors contributing to the cholesterol lowering effect. Consequently, these results indicate the potential use of CO defatted pulp as a cholesterol lowering and antioxidant agent.
研究了齿叶黄皮（CO）果实部分对高胆固醇血症兔的作用。将 49 只兔子随机分为 7 组，每组 7 只（n = 7），用含有 CO 果实不同部分的饮食喂养 8 周。分组如下：（1）正常饮食：NC 组和（2）高胆固醇饮食：PC、HS（10mg/kg/天辛伐他汀）、HPO（20g/kg(-1) 从 CO 果肉中提取的油）、HKO（20g/kg(-1) 从 CO 核仁中提取的油）、HF（50g/kg(-1) CO 全脂果肉）和 HD（50g/kg(-1) CO 脱脂果肉）。在这些组中，摄入 CO 脱脂果肉的兔子表现出最大的降胆固醇作用，因为它降低了血浆 LDL-C、TC 和硫代巴比妥酸反应物质（TBARS）水平以及动脉粥样硬化斑块。高膳食纤维和抗氧化活性的存在是其降胆固醇作用的潜在因素。因此，这些结果表明 CO 脱脂果肉具有作为降胆固醇和抗氧化剂的潜力。
