Bone Health Service, Charles Salt Laboratories, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, Oswestry, Shropshire, SY10 7AG, UK.
Osteoporos Int. 2012 Dec;23(12):2749-68. doi: 10.1007/s00198-012-2050-6. Epub 2012 Jul 20.
To review whether osteoporosis in the absence of vertebral fracture (VFX) affects health-related quality of life (HRQoL), a systematic search of the main literature databases for HRQoL in patients with osteoporosis without VFX was undertaken. This was undertaken. This identified 1,327 articles as potentially relevant to the review. After screening of abstracts and reviewing 168 articles in detail, 27 were considered relevant. HRQoL data were extracted and collated into tables and, where possible, were converted into normative scores and further analysed. Data relating to the associations between HRQoL and bone mineral density (BMD) were also collated. Of the 27 articles included, only 5 directly compared osteoporosis without VFX with a control group (BMD T-score > -1.0, without VFX). Extracted raw data from 21 articles demonstrated that patients with osteoporosis without VFX had clinically relevant reductions in role physical, general health, vitality, mental health domains and the mental component summary score, using SF36. Using Qualeffo-41, pain and physical function were worse in these patients. Also, HRQoL was related to upper femur, but not lumbar spine BMD. HRQoL data in patients with osteoporosis without VFX are limited and variable but suggest that HRQoL is adversely affected by osteoporosis in the absence of VFX. The association of lower BMD and worse HRQoL suggests that more attention should be paid to HRQoL in those without VFX. Future studies are needed to investigate HRQoL in patients with osteoporosis in the absence of fracture, controlling for co-morbidities and social and economic status.
为了评估无椎体骨折（VFX）的骨质疏松症是否影响健康相关生活质量（HRQoL），对无 VFX 的骨质疏松症患者的 HRQoL 主要文献数据库进行了系统检索。确定了 1327 篇可能与综述相关的文章。在筛选摘要并详细审查了 168 篇文章后，认为 27 篇文章与综述相关。提取了 HRQoL 数据并制成表格，在可能的情况下，将其转换为规范评分并进一步分析。还整理了与 HRQoL 与骨密度（BMD）之间的关联相关的数据。在所纳入的 27 篇文章中，只有 5 篇文章直接将无 VFX 的骨质疏松症与对照组进行了比较（BMD T 评分> -1.0，无 VFX）。从 21 篇文章中提取的原始数据表明，无 VFX 的骨质疏松症患者在角色身体、一般健康、活力、心理健康领域以及 SF36 的精神成分综合评分方面存在临床相关的降低。使用 Qualeffo-41，这些患者的疼痛和身体功能更差。此外，HRQoL 与股骨上段有关，与腰椎 BMD 无关。无 VFX 的骨质疏松症患者的 HRQoL 数据有限且多变，但表明 HRQoL 受到无 VFX 的骨质疏松症的不利影响。较低的 BMD 和较差的 HRQoL 之间的关联表明，应更加关注无 VFX 的患者的 HRQoL。需要进一步的研究来调查无骨折的骨质疏松症患者的 HRQoL，同时控制共病和社会经济状况。
