Hawkins Roland B
Department of Radiation Oncology, Ochsner Clinic Foundation, New Orleans, LA.
Ochsner J. 2002 Summer;4(3):168-75.
Patients who undergo apparently curative low anterior or abdominal-perineal resection of locally advanced carcinoma of the rectum have a significant rate of local pelvic recurrence and death from cancer in the years following surgery. Pre- and postoperative irradiation and chemotherapy in various combinations and schedules have been recommended to improve the outcome for these patients. Several randomized trials have evaluated the effectiveness of adjuvant and neoadjuvant treatments in improving survival and reducing the rate of pelvic recurrence with a combination of radiation and chemotherapy. There is some evidence that preoperative treatment with radiation is more effective than postoperative treatment. The treatment program preferred at Ochsner is described.
接受局部晚期直肠癌根治性低位前切除术或腹会阴联合切除术的患者，术后数年局部盆腔复发和死于癌症的发生率较高。已推荐采用多种组合和方案的术前及术后放疗和化疗，以改善这些患者的治疗效果。多项随机试验评估了辅助治疗和新辅助治疗联合放疗和化疗在提高生存率及降低盆腔复发率方面的有效性。有证据表明，术前放疗比术后放疗更有效。本文描述了奥施纳医院所采用的首选治疗方案。
