多瘤病毒。早期区域及其T抗原。
Polyoma virus. The early region and its T-antigens.
作者信息
Soeda E, Arrand J R, Griffin B E
出版信息
Nucleic Acids Res. 1979 Oct 25;7(4):839-57. doi: 10.1093/nar/7.4.839.
Abstract
The DNA sequence of the early coding region of polyoma virus is presented. It consists of 2739 nucleotides. The sequence predicts that more than one reading frame can be used to code for the three known polyoma virus early proteins (designated small, middle and large T-antigens). From the DNA sequence, the 'splicing' signals used in the processing of viral RNA to functional messenger RNAs can be predicted, as well as the sizes and sequences of the three proteins. Other unusual aspects of the DNA sequence are noted. Comparisons are made between the DNA sequences and the predicted amino acid sequences of the respective large T-antigens of polyoma virus and the related virus Simian Virus (SV) 40.
摘要
本文展示了多瘤病毒早期编码区的DNA序列。它由2739个核苷酸组成。该序列预测，不止一个阅读框可用于编码三种已知的多瘤病毒早期蛋白（分别称为小T抗原、中T抗原和大T抗原）。从DNA序列中，可以预测出病毒RNA加工成功能性信使RNA时所使用的“剪接”信号，以及这三种蛋白质的大小和序列。文中还指出了该DNA序列的其他异常之处。对多瘤病毒和相关病毒猴病毒（SV）40各自大T抗原的DNA序列和预测的氨基酸序列进行了比较。
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1
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Proc Natl Acad Sci U S A. 1974 May;71(5):2077-81. doi: 10.1073/pnas.71.5.2077.
2
A colinear map relating the simian virus 40 (SV40) DNA segments of six adenovirus-SV40 hybrids to the DNA fragments produced by restriction endonuclease cleavage of SV40 DNA.一种共线性图谱，它将六种腺病毒 - 猴病毒40（SV40）杂交体的SV40 DNA片段与通过SV40 DNA限制性内切酶切割产生的DNA片段联系起来。
Proc Natl Acad Sci U S A. 1974 Feb;71(2):441-5. doi: 10.1073/pnas.71.2.441.
3
3' non-coding region sequences in eukaryotic messenger RNA.真核生物信使核糖核酸中的3'非编码区序列。
Nature. 1976 Sep 16;263(5574):211-4. doi: 10.1038/263211a0.
4
Restriction endonucleases.限制性内切核酸酶
CRC Crit Rev Biochem. 1976 Nov;4(2):123-64. doi: 10.3109/10409237609105456.
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