5%咪喹莫特乳膏治疗1例经典型卡波西肉瘤患者的疗效
Efficacy of 5% imiquimod cream in a patient with classic Kaposi sarcoma.
作者信息
Gündüz Kamer, Günay Umran, Inanir Işıl, Gençoğlan Gülsüm, Temiz Peyker
机构信息
Department of Dermatology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
出版信息
J Dermatol Case Rep. 2012 Jun 30;6(2):52-3. doi: 10.3315/jdcr.2012.1099.
BACKGROUND
The classic Kaposi sarcoma is most common in the Mediterranean population over 50 years of age and presents with reddish-brown papules and nodules particularly on the lower limbs. Treatment depends on the clinical presentation and extension of lesions. Imiquimod is as an immune response modifier with antiangiogenic activity.
MAIN OBSERVATIONS
We present a 74-year-old man with classic Kaposi sarcoma who had multiple, small, violaceous papules and nodules on the trunk and extremities with a history of 14 years. He complained particularly from plantar hyperkeratotic painful nodules. Treatment with imiquimod 5% cream under occlusion resulted with almost complete regression within 12 weeks. No local or systemic side effects were observed.
CONCLUSIONS
Topical imiquimod was a safe and effective therapy in our patient with classic Kaposi sarcoma.
背景
经典型卡波西肉瘤在50岁以上的地中海人群中最为常见，表现为红棕色丘疹和结节，尤其多见于下肢。治疗取决于病变的临床表现和范围。咪喹莫特是一种具有抗血管生成活性的免疫反应调节剂。
主要观察结果
我们报告一名74岁患有经典型卡波西肉瘤的男性，其躯干和四肢有多个小的紫蓝色丘疹和结节，病史长达14年。他特别抱怨足底有角化过度的疼痛性结节。采用5%咪喹莫特乳膏封包治疗，12周内几乎完全消退。未观察到局部或全身副作用。
结论
局部应用咪喹莫特对我们这位患有经典型卡波西肉瘤的患者是一种安全有效的治疗方法。
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