Cole M G, Prchal J F
Age Ageing. 1984 Mar;13(2):101-5. doi: 10.1093/ageing/13.2.101.
Serum vitamin B12 levels (as determined by radio-immunoassay) were measured in 20 subjects aged 65 years and over with Alzheimer-type dementia, 20 age-matched subjects with non-Alzheimer type dementia and 20 age-matched subjects with no dementia. Serum vitamin B12 levels were significantly lower and serum vitamin B12 deficiency was significantly more frequent in subjects with Alzheimer-type dementia and were independent of age, sex, haematological abnormality or serum folate.
通过放射免疫测定法测定了20名65岁及以上患阿尔茨海默型痴呆症的受试者、20名年龄匹配的非阿尔茨海默型痴呆症受试者以及20名年龄匹配的无痴呆症受试者的血清维生素B12水平。阿尔茨海默型痴呆症受试者的血清维生素B12水平显著较低，血清维生素B12缺乏症的发生率显著更高，且与年龄、性别、血液学异常或血清叶酸无关。
