Ikeda T, Furukawa Y, Mashimoto S, Takahashi K, Yamada M
Department of Neuropsychiatry, Yamaguchi University, School of Medicine, Ube, Japan.
Acta Psychiatr Scand. 1990 Oct;82(4):327-9. doi: 10.1111/j.1600-0447.1990.tb01395.x.
Vitamin B12 levels in the serum and the cerebrospinal fluid (CSF) were compared between patients with Alzheimer's disease (AD) and senile dementia of Alzheimer's type (SDAT) (AD group) and patients with multi-infarct dementia (MID group). The B12 levels in the serum and the CSF were 742 +/- 359 pg/ml and 28 +/- 7 pg/ml (mean +/- SD), respectively, in the AD group, and 962 +/- 254 pg/ml and 50 +/- 26 pg/ml, respectively, in the MID group. CSF B12 levels were significantly lower in the AD group than in the MID group, whereas the serum levels were not different. At the same time, the serum levels of almost all patients were within the normal range, whereas the CSF levels were 25 pg/ml or lower in 10 of 12 AD patients. Therefore, this low level in the CSF is considered to be a characteristic finding in the AD group.
比较了阿尔茨海默病（AD）和阿尔茨海默型老年痴呆症（SDAT）患者（AD组）与多发梗死性痴呆患者（MID组）血清和脑脊液（CSF）中的维生素B12水平。AD组血清和脑脊液中的B12水平分别为742±359 pg/ml和28±7 pg/ml（平均值±标准差），MID组分别为962±254 pg/ml和50±26 pg/ml。AD组脑脊液B12水平显著低于MID组，而血清水平无差异。同时，几乎所有患者的血清水平都在正常范围内，而12例AD患者中有10例脑脊液水平为25 pg/ml或更低。因此，脑脊液中的这种低水平被认为是AD组的一个特征性表现。
