Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Res Vet Sci. 2012 Dec;93(3):1139-41. doi: 10.1016/j.rvsc.2012.07.007. Epub 2012 Jul 24.
The aim of the study was to investigate the effect of a modified glucomannan binder on the course of a Salmonella Typhimurium infection in pigs. Therefore, four pig diets were provided during 23 days: (1) free of mycotoxins, (2) containing 1g binder per kg feed, (3) containing 83 μg T-2 toxin per kg feed and (4) containing 83 μg T-2 toxin and 1g binder per kg feed. After 18 days, all pigs were inoculated with Salmonella Typhimurium and euthanized five days later. The addition of the binder to T-2 toxin contaminated feed counteracted the reduced weight gain of pigs caused by T-2 toxin and reduced the amount of Salmonella Typhimurium in the cecum and cecal contents. In vitro findings might indicate that the binder captures Salmonella. We thus conclude that the binder counteracts T-2 toxin induced weight loss and possibly binds Salmonella, resulting in a reduced cecal colonization.
本研究旨在探讨一种改良葡甘露聚糖黏合剂对猪感染鼠伤寒沙门氏菌病程的影响。因此，在 23 天的时间里，给猪提供了四种饲料：（1）无霉菌毒素，（2）每公斤饲料含 1 克黏合剂，（3）每公斤饲料含 83 纳克 T-2 毒素，（4）每公斤饲料含 83 纳克 T-2 毒素和 1 克黏合剂。18 天后，所有猪都接种了鼠伤寒沙门氏菌，并在五天后安乐死。将黏合剂添加到 T-2 毒素污染的饲料中，可抵消 T-2 毒素引起的猪体重增加减少，并减少盲肠和盲肠内容物中的鼠伤寒沙门氏菌数量。体外研究结果可能表明，黏合剂可以捕获沙门氏菌。因此，我们得出结论，黏合剂可对抗 T-2 毒素引起的体重减轻，并可能结合沙门氏菌，从而减少盲肠定植。
