Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA.
Obesity (Silver Spring). 2012 Oct;20(10):2147-50. doi: 10.1038/oby.2012.170. Epub 2012 Jun 22.
Levels of four urinary F(2)-isoprostanes (F(2)-IsoPs) were examined in a large sample of the Insulin Resistance Atherosclerosis Study (IRAS) multiethnic cohort: 237 African Americans (AAs), 342 non-Hispanic whites (NHWs), and 275 Hispanic whites (HWs). F(2)-IsoP isomers - iPF2a-III, 2,3-dinor-iPF2a-III, iPF2a-VI, and 8,12-iso-iPF2a-VI - were measured in 854 urine samples using liquid chromatography with tandem mass spectrometry detection. In AAs, levels of all four F(2)-IsoPs were lower compared with NHWs and HWs (P values <0.05). When stratified by BMI, this gap was not observed among participants with normal BMI but appeared among overweight participants and increased among obese participants. Examining the slopes of the associations between BMI and F(2)-IsoPs showed no association between these variables among AAs (P values >0.2), and positive associations among whites (P values <0.05). Taking into account that positive cross-sectional associations between systemic F(2)-IsoP levels and BMI have been consistently demonstrated in many study populations, the lack of such an association among AAs reveals a new facet of racial/ethnic differences in obesity-related risk profiles.
在胰岛素抵抗动脉粥样硬化研究（IRAS）多民族队列的一个大样本中，检查了四种尿 F（2）-异前列烷（F（2）-IsoPs）的水平：237 名非裔美国人（AA）、342 名非西班牙裔白人（NHW）和 275 名西班牙裔白人（HW）。使用液相色谱-串联质谱检测法在 854 个尿液样本中测量了 F（2）-IsoP 异构体-iPF2a-III、2,3-二降-iPF2a-III、iPF2a-VI 和 8,12-异-iPF2a-VI。与 NHW 和 HW 相比，所有四种 F（2）-IsoP 的水平在 AA 中均较低（P 值均<0.05）。按 BMI 分层时，在 BMI 正常的参与者中未观察到这种差异，但在超重参与者中出现，并且在肥胖参与者中增加。检查 BMI 和 F（2）-IsoP 之间关联的斜率，在 AA 中这些变量之间没有关联（P 值均>0.2），而在白人中存在关联（P 值均<0.05）。考虑到在许多研究人群中已经一致证明了系统性 F（2）-IsoP 水平与 BMI 之间存在正的横断面关联，而在 AA 中不存在这种关联揭示了肥胖相关风险特征的种族/民族差异的一个新方面。
