Department of Biomedical Sciences, Unit of Veterinary Protozoology, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.
J Invertebr Pathol. 2013 Mar;112 Suppl:S142-7. doi: 10.1016/j.jip.2012.07.020. Epub 2012 Jul 25.
To date, IAEA-supported Sterile Insect Technique (SIT) projects for tsetse and trypanosomiasis control have been in areas without human sleeping sickness, but future projects could include areas of actual or potential human disease transmission. In this context it would be imperative that released sterile tsetse flies are incompetent to transmit the disease-causing trypanosome parasite. Therefore, development of tsetse fly strains refractory to trypanosome infection is highly desirable as a simple and effective method of ensuring vector incompetence of the released flies. This new IAEA Coordinated Research Project (CRP) focuses on gaining a deeper knowledge of the tripartite interactions between the tsetse fly vectors, their symbionts and trypanosome parasites. The objective of this CRP is to acquire a better understanding of mechanisms that limit the development of trypanosome infections in tsetse and how these may be enhanced.
迄今为止，原子能机构支持的采采蝇和锥虫病控制的无菌昆虫技术（SIT）项目都在没有人患昏睡病的地区进行，但未来的项目可能包括实际或潜在的人类疾病传播地区。在这种情况下，至关重要的是，释放的无菌采采蝇不能传播引起疾病的锥虫寄生虫。因此，开发对锥虫感染具有抗性的采采蝇品系是确保释放的苍蝇不具有媒介能力的一种简单而有效的方法。这个新的国际原子能机构协调研究项目（CRP）专注于更深入地了解采采蝇媒介、共生体和锥虫寄生虫之间的三方相互作用。该 CRP 的目标是更好地了解限制采采蝇中锥虫感染发展的机制，以及如何增强这些机制。
