Biotechnology Research Institute, Kenya Agricultural & Livestock Research Organization, P.O Box 57811, 00200, Kaptagat Rd, Loresho, Nairobi, Kenya.
Insect Pest Control Laboratory, FAO/IAEA Agriculture & Biotechnology Laboratory, IAEA Laboratories Seibersdorf, A-2444, Seibersdorf, Austria.
BMC Microbiol. 2018 Nov 23;18(Suppl 1):179. doi: 10.1186/s12866-018-1280-y.
With the absence of effective prophylactic vaccines and drugs against African trypanosomosis, control of this group of zoonotic neglected tropical diseases depends the control of the tsetse fly vector. When applied in an area-wide insect pest management approach, the sterile insect technique (SIT) is effective in eliminating single tsetse species from isolated populations. The need to enhance the effectiveness of SIT led to the concept of investigating tsetse-trypanosome interactions by a consortium of researchers in a five-year (2013-2018) Coordinated Research Project (CRP) organized by the Joint Division of FAO/IAEA. The goal of this CRP was to elucidate tsetse-symbiome-pathogen molecular interactions to improve SIT and SIT-compatible interventions for trypanosomoses control by enhancing vector refractoriness. This would allow extension of SIT into areas with potential disease transmission. This paper highlights the CRP's major achievements and discusses the science-based perspectives for successful mitigation or eradication of African trypanosomosis.
由于缺乏针对非洲锥虫病的有效预防疫苗和药物，因此控制这类人畜共患的被忽视热带病依赖于控制采采蝇媒介。当在区域范围的虫害管理方法中应用时，不育昆虫技术（SIT）可有效从隔离种群中消除单一采采蝇物种。为了提高 SIT 的有效性，一个由研究人员组成的联合体提出了通过五年（2013-2018 年）粮农组织/国际原子能机构联合司组织的协调研究项目（CRP）调查采采蝇-锥虫相互作用的概念。该 CRP 的目标是阐明采采蝇共生体-病原体分子相互作用，以提高 SIT 和 SIT 相容的干预措施，通过增强媒介抗性来控制锥虫病。这将允许 SIT 扩展到具有潜在疾病传播的地区。本文重点介绍了 CRP 的主要成就，并讨论了成功减轻或根除非洲锥虫病的基于科学的观点。
