Munoz C, Endres S, van der Meer J, Schlesinger L, Arevalo M, Dinarello C
Division of Geographic Medicine and Infectious Diseases, New England Medical Center Hospitals, Boston, MA.
Res Immunol. 1990 Jul-Aug;141(6):505-13. doi: 10.1016/0923-2494(90)90019-u.
The two forms of interleukin-1, IL-1 alpha and IL-1 beta respectively, and tumour necrosis factor (TNF) are polypeptides sharing different biological activities which are often associated with host defence mechanisms. Because of the well-recognized benefits of breast feeding for newborns, colostrum from 9 healthy lactating women was analysed for the presence of these 3 cytokines. Specific radioimmunoassay revealed that colostrum contains a significant amount of IL-1 beta (mean +/- SEM values of 1,130 +/- 259 pg/ml). The concentrations of IL-1 alpha and TNF were negligible. Colostral leukocytes are able to produce IL-1 since high activity was found after stimulation with Staphylococcus epidermidis. In addition, these cells produced IL-1 spontaneously in vitro, in contrast to resting maternal blood monocytes. As IL-1 increases resistance to infection, the presence of this cytokine represent a beneficial aspect of breast feeding.
白细胞介素-1有两种形式，分别是IL-1α和IL-1β，肿瘤坏死因子（TNF）是具有不同生物学活性的多肽，它们常与宿主防御机制相关。鉴于母乳喂养对新生儿的益处已得到广泛认可，对9名健康哺乳期妇女的初乳进行了这三种细胞因子的检测。特异性放射免疫分析显示，初乳中含有大量的IL-1β（平均±标准误为1130±259 pg/ml）。IL-1α和TNF的浓度可忽略不计。初乳中的白细胞能够产生IL-1，因为在用表皮葡萄球菌刺激后发现了高活性。此外，与静息的母体血液单核细胞不同，这些细胞在体外可自发产生IL-1。由于IL-1可增强抗感染能力，这种细胞因子的存在代表了母乳喂养的一个有益方面。
