Banu Asima, Sathyanarayana Bc, Chattannavar Goura
Bangalore Medical College and Research Institute.
Australas Med J. 2012;5(6):305-9. doi: 10.4066/AMJ.2012.1301. Epub 2012 Jun 30.
Infected leg ulcers are major health problems resulting in morbidity and disability and are usually chronic and refractory to antimicrobial treatment.
The present study is aimed at determining the bacteria involved in leg ulcers and their resistance patterns to commonly used antibiotics as well as to determine whether Aloe Vera has antibacterial activity against multi-drug resistant organisms and promotes wound healing.
A total of 30 cases with leg ulcers infected with multi-drug resistant organisms were treated with topical aloe vera gel and 30 age and sex-matched controls were treated with topical antibiotics. Culture and sensitivity was done from the wounds on alternate days and the ulcer was clinically and microbiologically assessed after 10 days. The results were compiled and statistically analysed.
Cultures of the study group who were using aloe vera dressings showed no growth by the fifth day in 10 (33.3%) cases, seventh day in another 16 (53.3%) and ninth day in two of the remaining four cases (6.7%) while in two (6.7%) cases there was no decrease in the bacterial count. This means that of the 30 cases, 28 showed no growth by the end of 11 days while two cases showed no decrease in bacterial count. Growth of bacteria in study group is decreased from 100% (30 cases) to 6.7% (2 cases) by day 11 with P<0.001. Cultures of the control group did not show any decrease in the bacterial growth by day 11.
Aloe vera gel preparation is cheap and was effective even against multi-drug resistant organisms as compared to the routinely used topical anti-microbial agents.
感染性腿部溃疡是导致发病和残疾的主要健康问题，通常病程较长，对抗菌治疗难治。
本研究旨在确定参与腿部溃疡的细菌及其对常用抗生素的耐药模式，以及确定芦荟是否对多重耐药菌具有抗菌活性并促进伤口愈合。
对30例感染多重耐药菌的腿部溃疡患者外用芦荟凝胶进行治疗，30例年龄和性别匹配的对照外用抗生素治疗。每隔一天从伤口进行培养和药敏试验，10天后对溃疡进行临床和微生物学评估。汇总结果并进行统计分析。
使用芦荟敷料的研究组培养物中，10例（33.3%）在第5天无细菌生长，另外16例（53.3%）在第7天无细菌生长，其余4例中的2例（6.7%）在第9天无细菌生长，而2例（6.7%）细菌计数未减少。这意味着30例患者中，28例在11天结束时无细菌生长，2例细菌计数未减少。研究组细菌生长从第1天的100%（30例）降至第11天的6.7%（2例），P<0.001。对照组培养物在第11天时细菌生长未显示任何减少。
与常规使用的局部抗菌剂相比，芦荟凝胶制剂价格便宜，甚至对多重耐药菌也有效。
